Genome control by SMC complexes
C Hoencamp, BD Rowland - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Many cellular processes require large-scale rearrangements of chromatin structure.
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …
New insights into genome folding by loop extrusion from inducible degron technologies
Chromatin folds into dynamic loops that often span hundreds of kilobases and physically
wire distant loci together for gene regulation. These loops are continuously created …
wire distant loci together for gene regulation. These loops are continuously created …
Multi-feature clustering of CTCF binding creates robustness for loop extrusion blocking and Topologically Associating Domain boundaries
Abstract Topologically Associating Domains (TADs) separate vertebrate genomes into
insulated regulatory neighborhoods that focus genome-associated processes. TADs are …
insulated regulatory neighborhoods that focus genome-associated processes. TADs are …
CTCF and R-loops are boundaries of cohesin-mediated DNA loo**
Cohesin and CCCTC-binding factor (CTCF) are key regulatory proteins of three-dimensional
(3D) genome organization. Cohesin extrudes DNA loops that are anchored by CTCF in a …
(3D) genome organization. Cohesin extrudes DNA loops that are anchored by CTCF in a …
TADs: Dynamic structures to create stable regulatory functions
JA da Costa-Nunes, D Noordermeer - Current Opinion in Structural Biology, 2023 - Elsevier
Mammalian chromosomes are organized at different length scales within the cell nucleus.
Topologically Associating Domains (TADs) are structural units of 3D genome organization …
Topologically Associating Domains (TADs) are structural units of 3D genome organization …
Pathological role of HDAC8: cancer and beyond
JY Kim, H Cho, J Yoo, GW Kim, YH Jeon, SW Lee… - Cells, 2022 - mdpi.com
Histone deacetylase 8 (HDAC8) is a class I HDAC that catalyzes the deacetylation of histone
and non-histone proteins. As one of the best-characterized isoforms, numerous studies have …
and non-histone proteins. As one of the best-characterized isoforms, numerous studies have …
NIPBL and cohesin: new take on a classic tale
D Alonso-Gil, A Losada - Trends in Cell Biology, 2023 - cell.com
Cohesin folds the genome in dynamic chromatin loops and holds the sister chromatids
together. NIPBL Scc2 is currently considered the cohesin loader, a role that may need …
together. NIPBL Scc2 is currently considered the cohesin loader, a role that may need …
Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms
Cohesin connects CTCF-binding sites and other genomic loci in cis to form chromatin loops
and replicated DNA molecules in trans to mediate sister chromatid cohesion. Whether …
and replicated DNA molecules in trans to mediate sister chromatid cohesion. Whether …
Structural basis of centromeric cohesion protection
A García-Nieto, A Patel, Y Li, R Oldenkamp… - Nature structural & …, 2023 - nature.com
In the early stages of mitosis, cohesin is released from chromosome arms but not from
centromeres. The protection of centromeric cohesin by SGO1 maintains the sister chromatid …
centromeres. The protection of centromeric cohesin by SGO1 maintains the sister chromatid …
Genetic determinants of micronucleus formation in vivo
DJ Adams, B Barlas, RE McIntyre, I Salguero… - Nature, 2024 - nature.com
Genomic instability arising from defective responses to DNA damage or mitotic
chromosomal imbalances can lead to the sequestration of DNA in aberrant extranuclear …
chromosomal imbalances can lead to the sequestration of DNA in aberrant extranuclear …