Simple Summary Lck is an important kinase that plays a key role in the physiological
responses of T lymphocytes as well as in several other tissues such as the lung, intestine …

Uveitis is the most common form of ocular lesions in Behcet's disease, severely affecting
visual function. Molecular pathological changes of ocular lesions in patients with Behcet's …

Psoriasis is a chronic dermal inflammatory disease with a world-wide prevalence in which
different immune/non-immune cells, eg T cells, macrophages, neutrophils, and keratinocytes …

Light-responsive molecular tools targeting kinases affords one the opportunity to study the
underlying cellular function of selected kinases. In efforts to externally control lymphocyte …

While the peripheral T-cell lymphomas (PTCL) remain a therapeutic challenge, and
increasingly account for a disproportionate number of lymphoma-related deaths, improved …

The lymphocyte-specific protein tyrosine kinase (LCK) is a critical target in leukemia
treatment. However, potential off-target interactions involving LCK can lead to unintended …

The lymphocyte-specific protein tyrosine kinase (LCK) plays a crucial role in both T-cell
development and activation. Dysregulation of LCK signaling has been demonstrated to drive …

Inhibition of PDE5 results in elevation of cGMP leading to vascular relaxation and reduction
in the systemic blood pressure. Therefore, PDE5 inhibitors are used as antihypertensive and …

Fenretinide is a synthetic retinoid compound, which induces apoptosis via generating
reactive oxygen species (ROS) and modulating PI3K/Akt/mTOR signalling pathway. We …

Although the sea ecosystem offers a broad range of bioactivities including anticancer, none
of the FDA-approved antiproliferative protein kinase inhibitors are derived from a marine …