The neural bases of tinnitus: lessons from deafness and cochlear implants

M Knipper, P Van Dijk, H Schulze, B Mazurek… - Journal of …, 2020 - jneurosci.org
Subjective tinnitus is the conscious perception of sound in the absence of any acoustic
source. The literature suggests various tinnitus mechanisms, most of which invoke changes …

Adult neurogenesis promotes balance recovery after vestibular loss

B Tighilet, C Chabbert - Progress in Neurobiology, 2019 - Elsevier
A phenomenon called vestibular compensation occurs after peripheral vestibular loss. This
process involves a mosaic of profound structural rearrangements within the vestibular …

Disturbed balance of inhibitory signaling links hearing loss and cognition

M Knipper, W Singer, K Schwabe… - Frontiers in Neural …, 2022 - frontiersin.org
Neuronal hyperexcitability in the central auditory pathway linked to reduced inhibitory
activity is associated with numerous forms of hearing loss, including noise damage, age …

[HTML][HTML] Sensorimotor rehabilitation promotes vestibular compensation in a rodent model of acute peripheral vestibulopathy by promoting microgliogenesis in the …

E Marouane, N El Mahmoudi, G Rastoldo, D Péricat… - Cells, 2021 - mdpi.com
Acute peripheral vestibulopathy leads to a cascade of symptoms involving balance and gait
disorders that are particularly disabling for vestibular patients. Vestibular rehabilitation …

Noise-induced hearing loss alters potassium-chloride cotransporter KCC2 and GABA inhibition in the auditory centers

V Parameshwarappa, MI Siponen, I Watabe… - Scientific Reports, 2024 - nature.com
Homeostatic plasticity, the ability of neurons to maintain their averaged activity constant
around a set point value, is thought to account for the central hyperactivity after hearing loss …

Adult and endemic neurogenesis in the vestibular nuclei after unilateral vestibular neurectomy

G Rastoldo, N El Mahmoudi, E Marouane… - Progress in …, 2021 - Elsevier
We previously revealed adult reactive neurogenesis in deafferented vestibular nuclei
following unilateral vestibular neurectomy (UVN) in the feline model. We recently replicated …

[HTML][HTML] L-Thyroxine improves vestibular compensation in a rat model of acute peripheral vestibulopathy: Cellular and behavioral aspects

G Rastoldo, E Marouane, N El-Mahmoudi, D Péricat… - Cells, 2022 - mdpi.com
Unilateral vestibular lesions induce a vestibular syndrome, which recovers over time due to
vestibular compensation. The therapeutic effect of L-Thyroxine (L-T4) on vestibular …

Breaking a dogma: acute anti-inflammatory treatment alters both post-lesional functional recovery and endogenous adaptive plasticity mechanisms in a rodent model …

N El Mahmoudi, G Rastoldo, E Marouane… - Journal of …, 2021 - Springer
Background Due to their anti-inflammatory action, corticosteroids are the reference treatment
for brain injuries and many inflammatory diseases. However, the benefits of acute …

Acute and long-term circuit-level effects in the auditory cortex after sound trauma

M Jeschke, MFK Happel, K Tziridis, P Krauss… - Frontiers in …, 2021 - frontiersin.org
Harmful environmental sounds are a prevailing source of chronic hearing impairments,
including noise induced hearing loss, hyperacusis, or tinnitus. How these symptoms are …

Changes in the spatiotemporal pattern of spontaneous activity across a cortical column after noise trauma

V Parameshwarappa, L Pezard… - Journal of …, 2022 - journals.physiology.org
In the auditory modality, noise trauma has often been used to investigate cortical plasticity as
it causes cochlear hearing loss. One limitation of these past studies, however, is that the …