High-fidelity DNA replication is critical for the faithful transmission of genetic information to
daughter cells. Following genotoxic stress, specialized DNA damage tolerance pathways …

Genetic abnormalities in the DNA repair genes BRCA1 and BRCA2 predispose to hereditary
breast and ovarian cancer (HBOC). However, only approximately 25% of cases of HBOC …

Gene-Panel Sequencing and the Prediction of Breast-Cancer Risk | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

The use of multigene panels for the assessment of cancer susceptibility is expanding rapidly
in clinical practice, particularly in the USA, despite concerns regarding the uncertain clinical …

Objectives Physical inactivity and sedentary behaviour are associated with higher breast
cancer risk in observational studies, but ascribing causality is difficult. Mendelian …

Repair of DNA interstrand crosslinks requires action of multiple DNA repair pathways,
including homologous recombination. Here, we report a de novo heterozygous T131P …

Introduction: Heritage is the most important risk factor for breast cancer. About 15–20% of
breast cancer is familial, referring to affected women who have one or more first-or second …

There are multiple applications of molecular tests in clinical oncology. Mutation analysis is
now routinely utilized for the diagnosis of hereditary cancer syndromes. Healthy carriers of …

Breast and ovarian cancers are some of the most common tumors in females, and the
genetic predisposition is emerging as one of the key risk factors in the development of these …

More than 15 years have passed since the identification, through linkage, of 'first-
wave'susceptibility genes for common cancers (BRCA1, BRCA2, MLH1 and MSH2). These …