Most tissues of the human body are characterized by highly anisotropic physical properties
and biological organization. Hydrogels have been proposed as scaffolding materials to …

Background The present article systematically reviews recent literature on the in vivo
adaptation of asymptomatic human tendons following increased chronic mechanical …

Tendon is a crucial component of the musculoskeletal system. Tendons connect muscle to
bone and transmit forces to produce motion. Chronic and acute tendon injuries are very …

Mechanical loading is an important factor in musculoskeletal health and disease. Tendons
and ligaments require physiological levels of mechanical loading to develop and maintain …

Tendon injuries are a global health problem that affects millions of people annually. The
properties of tendons make their natural rehabilitation a very complex and long-lasting …

The development of intelligent materials, in particular those showing the highly sensitive
mechanoresponsive luminescence (MRL), is desirable but challenging. Here we report a …

Stem cells hold great promise for widespread biomedical applications, for which stem cell
fate needs to be well tailored. Besides biochemical cues, accumulating evidence has …

Engineering synthetic scaffolds to repair and regenerate ruptured native tendon and
ligament (T/L) tissues is a significant engineering challenge due to the need to satisfy both …

Tendons are dense connective tissues with a hierarchical polarized structure that respond to
and adapt to the transmission of muscle contraction forces to the skeleton, enabling motion …

Tendons and ligaments are extracellular matrix (ECM)-rich structures that interconnect
muscles and bones. Recent work has shown how tendon fibroblasts (tenocytes) interact with …