[HTML][HTML] Preservation of biomaterials and cells by freeze-drying: Change of paradigm
Freeze-drying is the most widespread method to preserve protein drugs and vaccines in a
dry form facilitating their storage and transportation without the laborious and expensive cold …
dry form facilitating their storage and transportation without the laborious and expensive cold …
Facts and evidences on the lyophilization of polymeric nanoparticles for drug delivery
Lyophilization has been used to improve the long-term stability of polymeric nanoparticles
for drug delivery applications, avoiding their instability in suspension. However, this …
for drug delivery applications, avoiding their instability in suspension. However, this …
Versatility of hydrogel-forming microneedles in in vitro transdermal delivery of tuberculosis drugs
Current therapy of tuberculosis (TB) has several limitations, such as risk of liver injury and
intestinal dysbiosis due to frequent oral administration of antibiotics. Transdermal …
intestinal dysbiosis due to frequent oral administration of antibiotics. Transdermal …
Parenteral protein formulations: an overview of approved products within the European Union
V Gervasi, RD Agnol, S Cullen, T McCoy… - European Journal of …, 2018 - Elsevier
The study presented is a comprehensive overview of commercial parenteral protein
formulations, approved by the European Medicines Agency (EMA), 1995–2018. The …
formulations, approved by the European Medicines Agency (EMA), 1995–2018. The …
Excipients in freeze-dried biopharmaceuticals: Contributions toward formulation stability and lyophilisation cycle optimisation
M Bjelošević, AZ Pobirk, O Planinšek… - International journal of …, 2020 - Elsevier
Biopharmaceuticals are one of the fastest growing areas within the pharmaceutical industry.
As protein drugs require parenteral administration, they are commonly formulated as …
As protein drugs require parenteral administration, they are commonly formulated as …
Lyophilized liposome-based parenteral drug development: Reviewing complex product design strategies and current regulatory environments
Y Wang, DW Grainger - Advanced drug delivery reviews, 2019 - Elsevier
Given the successful entry of several liposomal drug products into market, and some with
decades of clinical efficacy, liposomal drug delivery systems have proven capabilities to …
decades of clinical efficacy, liposomal drug delivery systems have proven capabilities to …
Excipients in parenteral formulations: selection considerations and effective utilization with small molecules and biologics
BM Rayaprolu, JJ Strawser… - Drug development and …, 2018 - Taylor & Francis
Excipients form a major component of pharmaceutical formulations and are classified as any
ingredient other than the active ingredient which is included within the product formulation to …
ingredient other than the active ingredient which is included within the product formulation to …
A lyophilized colorimetric RT-LAMP test kit for rapid, low-cost, at-home molecular testing of SARS-CoV-2 and other pathogens
Access to fast and reliable nucleic acid testing continues to play a key role in controlling the
COVID-19 pandemic, especially in the context of increased vaccine break-through risks due …
COVID-19 pandemic, especially in the context of increased vaccine break-through risks due …
Freeze-drying process for the fabrication of collagen-based sponges as medical devices in biomedical engineering
C Katrilaka, N Karipidou, N Petrou, C Manglaris… - Materials, 2023 - mdpi.com
This paper presents a systematic review of a key sector of the much promising and rapidly
evolving field of biomedical engineering, specifically on the fabrication of three-dimensional …
evolving field of biomedical engineering, specifically on the fabrication of three-dimensional …
Lyophilization of small-molecule injectables: an industry perspective on formulation development, process optimization, scale-up challenges, and drug product quality …
Lyophilization is a pivotal manufacturing process to obtain a stable drug product that is
unstable as a ready-to-use formulation. Some formulations may require the addition of drug …
unstable as a ready-to-use formulation. Some formulations may require the addition of drug …