Mitochondria and cell death-associated inflammation
E Vringer, SWG Tait - Cell Death & Differentiation, 2023 - nature.com
Mitochondria have recently emerged as key drivers of inflammation associated with cell
death. Many of the pro-inflammatory pathways activated during cell death occur upon …
death. Many of the pro-inflammatory pathways activated during cell death occur upon …
The cGAS–STING pathway as a therapeutic target in inflammatory diseases
A Decout, JD Katz, S Venkatraman… - Nature Reviews …, 2021 - nature.com
The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …
Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy
CD8+ T cell-mediated cancer clearance is often suppressed by the interaction between
inhibitory molecules like PD-1 and PD-L1, an interaction acts like brakes to prevent T cell …
inhibitory molecules like PD-1 and PD-L1, an interaction acts like brakes to prevent T cell …
STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer
PARP inhibitors (PARPi) have drastically changed the treatment landscape of advanced
ovarian tumors with BRCA mutations. However, the impact of this class of inhibitors in …
ovarian tumors with BRCA mutations. However, the impact of this class of inhibitors in …
An orally available non-nucleotide STING agonist with antitumor activity
BS Pan, SA Perera, JA Piesvaux, JP Presland… - Science, 2020 - science.org
INTRODUCTION Activation of the STING (stimulator of interferon genes) protein by its
natural ligand, cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) …
natural ligand, cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) …
Structures and mechanisms in the cGAS-STING innate immunity pathway
Besides its role as the blueprint of life, DNA can also alert the cell to the presence of
microbial pathogens as well as damaged or malignant cells. A major sensor of DNA that …
microbial pathogens as well as damaged or malignant cells. A major sensor of DNA that …
Mitochondrial DNA in inflammation and immunity
Mitochondria are cellular organelles that orchestrate a vast range of biological processes,
from energy production and metabolism to cell death and inflammation. Despite this …
from energy production and metabolism to cell death and inflammation. Despite this …
Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic
Stimulator of interferon genes (STING) links innate immunity to biological processes ranging
from antitumor immunity to microbiome homeostasis. Mechanistic understanding of the …
from antitumor immunity to microbiome homeostasis. Mechanistic understanding of the …
The balance of STING signaling orchestrates immunity in cancer
KRB Lanng, EL Lauridsen, MR Jakobsen - Nature Immunology, 2024 - nature.com
Over the past decade, it has become clear that the stimulator of interferon genes (STING)
pathway is critical for a variety of immune responses. This endoplasmic reticulum-anchored …
pathway is critical for a variety of immune responses. This endoplasmic reticulum-anchored …
STING cyclic dinucleotide sensing originated in bacteria
Stimulator of interferon genes (STING) is a receptor in human cells that senses foreign cyclic
dinucleotides that are released during bacterial infection and in endogenous cyclic GMP …
dinucleotides that are released during bacterial infection and in endogenous cyclic GMP …