Impact of bacterial metabolites on gut barrier function and host immunity: a focus on bacterial metabolism and its relevance for intestinal inflammation

N Gasaly, P De Vos, MA Hermoso - Frontiers in immunology, 2021 - frontiersin.org
The diverse and dynamic microbial community of the human gastrointestinal tract plays a
vital role in health, with gut microbiota supporting the development and function of the gut …

Interaction between microbiota and immunity in health and disease

D Zheng, T Liwinski, E Elinav - Cell research, 2020 - nature.com
The interplay between the commensal microbiota and the mammalian immune system
development and function includes multifold interactions in homeostasis and disease. The …

Imbalanced gut microbiota fuels hepatocellular carcinoma development by sha** the hepatic inflammatory microenvironment

KM Schneider, A Mohs, W Gui, EJC Galvez… - Nature …, 2022 - nature.com
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide,
and therapeutic options for advanced HCC are limited. Here, we observe that intestinal …

Inflammasome activation and regulation: toward a better understanding of complex mechanisms

D Zheng, T Liwinski, E Elinav - Cell discovery, 2020 - nature.com
Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …

The microbiota-gut-brain axis

JF Cryan, KJ O'Riordan, CSM Cowan… - Physiological …, 2019 - journals.physiology.org
I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …

Gut microbiota alters host bile acid metabolism to contribute to intrahepatic cholestasis of pregnancy

B Tang, L Tang, S Li, S Liu, J He, P Li, S Wang… - Nature …, 2023 - nature.com
Intrahepatic cholestasis of pregnancy (ICP) is a female pregnancy-specific disorder that is
characterized by increased serum bile acid and adverse fetal outcomes. The aetiology and …

[HTML][HTML] Perturbation of the gut microbiome by Prevotella spp. enhances host susceptibility to mucosal inflammation

A Iljazovic, U Roy, EJC Gálvez, TR Lesker, B Zhao… - Mucosal …, 2021 - Elsevier
Diverse microbial signatures within the intestinal microbiota have been associated with
intestinal and systemic inflammatory diseases, but whether these candidate microbes …

The intestinal epithelium: central coordinator of mucosal immunity

JM Allaire, SM Crowley, HT Law, SY Chang, HJ Ko… - Trends in …, 2018 - cell.com
The gastrointestinal (GI) tract represents a unique challenge to the mammalian immune
system. It must tolerate the presence of the luminal microbiota and thus not respond to their …

Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome

Z Zhang, H Tang, P Chen, H **e, Y Tao - Signal transduction and …, 2019 - nature.com
The trillions of microorganisms in the gut microbiome have attracted much attention recently
owing to their sophisticated and widespread impacts on numerous aspects of host …