The Rab family of small GTPases regulates intracellular membrane trafficking by
orchestrating the biogenesis, transport, tethering, and fusion of membrane‐bound …

Serotonin is a phylogenetically ancient biogenic amine that has played an integral role in
maintaining energy homeostasis for billions of years. In mammals, serotonin produced …

Blood glucose levels are tightly controlled by the coordinated action of at least four cell types
constituting pancreatic islets. Changes in the proportion and/or function of these cells are …

Maintenance of systemic homeostasis and the response to nutritional and environmental
challenges require the coordination of multiple organs and tissues. To respond to various …

Abstract Mitochondrial uncoupling protein 1 (UCP1) is enriched within interscapular brown
adipose tissue (iBAT) and beige (also known as brite) adipose tissue,, but its thermogenic …

Platelet-derived peripheral serotonin has pleiotropic effects on coagulation, metabolism,
tissue regeneration, and cancer growth; however, the effect of serotonin on the tumor …

Serotonin was first discovered in the gut, and its conventional actions as an intercellular
signalling molecule in the intrinsic and extrinsic enteric reflexes are well recognized, as are …

Transglutaminases (TGs) are multifunctional proteins having enzymatic and scaffolding
functions that participate in regulation of cell fate in a wide range of cellular systems and are …

Abstract Serotonin (5-hydroxytryptamine or 5-HT) is a multifunctional bioamine with
important signaling roles in a range of physiological pathways. Almost all of the 5-HT in our …

Type 2 diabetes mellitus (T2DM) is one of the most risk factors threatening human health.
Although genetic and environmental factors contribute to the development of T2DM, gut …