Discovery and validation of a novel inhibitor of HYPE-mediated AMPylation

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Small molecule FICD inhibitors suppress endogenous and pathologic FICD-mediated protein AMPylation

BK Chatterjee, M Alam, A Chakravorty, SM Lacy… - …, 2024 - pmc.ncbi.nlm.nih.gov
The AMP transferase, FICD, is an emerging drug target finetuning stress signaling in the
endoplasmic reticulum (ER). FICD is a bi-functional enzyme, catalyzing both AMP addition …
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