T‐cell activation is mediated by antigen‐specific signals from the TCRζ/CD3 and CD4–CD8–
p56lck complexes in combination with additional co‐signals provided by coreceptors such …

Celiac disease has become one of the best-understood HLA-linked disorders. Although it
shares many immunologic features with inflammatory bowel disease, celiac disease is …

The disease mechanisms of complex inflammatory disorders are difficult to define because
of extensive interactions between genetic and environmental factors. Coeliac disease is a …

Over the years, immune checkpoint inhibitors (CPIs) have become a powerful treatment
strategy in the field of cancer immunotherapy. In the last decade, the number of FDA …

CD28 costimulation regulates a wide range of cellular processes, from proliferation and
survival to promoting the differentiation of specialized T-cell subsets. Since first being …

Celiac disease is a multifactorial disease with complex genetics. Both HLA and non-HLA
genes contribute to the genetic component, but recent findings suggest that the importance …

Celiac disease (CD) is a complex genetic disorder with multiple contributing genes. Linkage
studies have identified several genomic regions that probably contain CD susceptibility …

Coeliac disease (gluten sensitive enteropathy) is a common, polygenic and multifactorial
disorder that serves as a pioneering model for the study of inflammatory disease. A major …

Aims: To investigate the natural history and incidence of autoimmune thyroiditis (AIT) in
paediatric patients with type 1 diabetes (T1D). Methods: Since 1990, annual screening for …

Autoimmune thyroid disease (AITD) comprises a series of interrelated conditions including
hyperthyroid Graves' disease (GD), Hashimoto's (goitrous) thyroiditis, atrophic autoimmune …