Immune-checkpoint inhibitors: long-term implications of toxicity
The development of immune-checkpoint inhibitors (ICIs) has heralded a new era in cancer
treatment, enabling the possibility of long-term survival in patients with metastatic disease …
treatment, enabling the possibility of long-term survival in patients with metastatic disease …
The role of PD-1 signaling in health and immune-related diseases
RY Chen, Y Zhu, YY Shen, QY Xu, HY Tang… - Frontiers in …, 2023 - frontiersin.org
Programmed cell death 1 receptor (PD-1) and its ligands constitute an inhibitory pathway to
mediate the mechanism of immune tolerance and provide immune homeostasis …
mediate the mechanism of immune tolerance and provide immune homeostasis …
Resident memory T cells form during persistent antigen exposure leading to allograft rejection
Tissue-resident memory T cells (TRM) contained at sites of previous infection provide local
protection against reinfection. Whether they form and function in organ transplants where …
protection against reinfection. Whether they form and function in organ transplants where …
Immune checkpoint inhibitors and acute kidney injury
P Zhou, Y Gao, Z Kong, J Wang, S Si, W Han… - Frontiers in …, 2024 - frontiersin.org
As a new type of anti-tumor immunotherapy, immune checkpoint inhibitors (ICIs) have
improved the prognosis of multiple malignancies. However, renal complications are …
improved the prognosis of multiple malignancies. However, renal complications are …
[HTML][HTML] Acute kidney injury induced by immune checkpoint inhibitors
R Tian, J Liang, R Li, X Zhou - Kidney Diseases, 2022 - karger.com
Background: Recent advances in immune therapy have focused on several agents that
target tumor suppression; specifically, use of immune checkpoint inhibitors (ICIs), such as …
target tumor suppression; specifically, use of immune checkpoint inhibitors (ICIs), such as …
[HTML][HTML] Immune-checkpoint inhibitors-induced type 1 diabetes mellitus: From Its molecular mechanisms to clinical practice
YK Cho, CH Jung - Diabetes & Metabolism Journal, 2023 - synapse.koreamed.org
With the increasing use of immune-checkpoint inhibitors (ICIs), such as anti-cytotoxic T
lymphocyte-associated antigen 4 (CTLA-4) and anti-programmed cell death-1 (PD-1), for the …
lymphocyte-associated antigen 4 (CTLA-4) and anti-programmed cell death-1 (PD-1), for the …
PD-1 immunology in the kidneys: a growing relationship
R Chen, Q Lin, H Tang, X Dai, L Jiang, N Cui… - Frontiers in …, 2024 - frontiersin.org
In recent years, knowledge regarding immune regulation has expanded rapidly, and major
advancements have been made in immunotherapy for immune-associated disorders …
advancements have been made in immunotherapy for immune-associated disorders …
[HTML][HTML] C/EBPα aggravates renal fibrosis in CKD through the NOX4-ROS-apoptosis pathway in tubular epithelial cells
Z **a, Z Wei, X Li, Y Liu, X Gu, S Huang… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Background Chronic kidney disease (CKD) is a prevalent renal disorder with various risk
factors. Emerging evidence indicates that the transcriptional factor CCAAT/enhancer binding …
factors. Emerging evidence indicates that the transcriptional factor CCAAT/enhancer binding …
Regulatory mechanisms of PD-1/PD-L1 in cancers
X Lin, K Kang, P Chen, Z Zeng, G Li, W **ong, M Yi… - Molecular Cancer, 2024 - Springer
Immune evasion contributes to cancer growth and progression. Cancer cells have the ability
to activate different immune checkpoint pathways that harbor immunosuppressive functions …
to activate different immune checkpoint pathways that harbor immunosuppressive functions …
Immune checkpoint inhibitor related nephrotoxicity: advances in clinicopathologic features, noninvasive approaches, and therapeutic strategy and rechallenge
Immune checkpoint inhibitors (ICIs) are used increasingly to treat more than 17 cancers and
have shown promising therapeutic results. However, ICI use can result in a variety of …
have shown promising therapeutic results. However, ICI use can result in a variety of …