The CXCR4 receptor upon binding its ligands triggers multiple signaling pathways that
orchestrate cell migration, hematopoiesis and cell homing, and retention in the bone …

Chemokines are chemotactic cytokines that promote cancer growth, metastasis, and
regulate resistance to chemotherapy. Stromal cell-derived factor 1 (SDF1) also known as …

Activation of the chemokine receptor CXCR4 by its chemokine ligand CXCL12 regulates
diverse cellular processes. Previously reported crystal structures of CXCR4 revealed the …

Chemokine receptors are members of the G protein-coupled receptor superfamily. These
receptors are intimately involved in cell movement, and thus play a critical role in several …

This study shows that five membrane proteins—three GPCRs, an ion channel, and an
enzyme—form self-clusters under natural expression levels in a cardiac-derived cell line …

Simple Summary Chemokines are small soluble proteins that control and regulate cell
trafficking within and between tissues by binding to their receptors. Among them, CXCL12 …

G protein-coupled receptors (GPCRs) are prominent drug targets responsible for
extracellular-to-intracellular signal transduction. GPCRs can form functional dimers that …

Although class AG protein− coupled receptors (GPCRs) can function as monomers, many of
them form dimers and oligomers, but the mechanisms and functional relevance of such …

Our understanding of the plasma membrane structure has undergone a major change since
the proposal of the fluid mosaic model of Singer and Nicholson in the 1970s. In this model …

While the existence and functional role of class C G-protein-coupled receptors (GPCR)
dimers is well established, there is still a lack of consensus regarding class A and B GPCR …