This perspective aims at celebrating the 100th anniversary of the discovery of the Passerini
three component reaction. After being nearly neglected for many years, now this reaction …

Highlights•OYE homologues (ene-reductases) are widely used for C double bond C-bond
reduction reactions.•Protein diversity screening and protein engineering aim at providing …

The enantioselective control of the three-component Passerini reaction was successfully
achieved using chiral phosphoric acid as a catalyst with a wide range of substrates and high …

A highly enantioselective ring-opening desymmetrization of meso-aziridines with
isocyanides was achieved in the presence of a chiral N, N′-dioxide/Mg (OTf) 2 complex …

Diastereoselectivity in Passerini and Ugi reactions of chiral aldehydes/imines remains
challenging. Moreover, the Ugi reaction of chiral acyclic imines is complicated by their easy …

2, 5-Bis (hydroxymethyl) tetrahydrofuran, a renewable building block, has been efficiently
desymmetrised to give either enantiomers of the corresponding monobutyrate in high ee …

Stefano Marcaccini was one of the pioneers in the use of isocyanide-based multicomponent
reactions in organic synthesis. Throughout his career at the University of Florence he …

While often multicomponent reactions (MCR) are used for the diversity-oriented synthesis of
racemic (or achiral) molecular entities, this short review describes two alternative …

Hydroamidation of carbon–carbon double bonds is an attractive strategy for installing
nitrogen functionality into molecular scaffolds and, with it, increasing molecular complexity …

A preparation of β-ketosulfides avoiding the use of thiols is described. The combination of a
multicomponent reaction and a lipase-catalysed hydrolysis has been developed in order to …