Prolyl isomerizations are intrinsically slow processes. They determine the rates of many
protein folding reactions and control regulatory events in folded proteins. Prolyl isomerases …

The order Rickettsiales includes species that cause a range of human diseases such as
human granulocytic anaplasmosis (Anaplasma phagocytophilum), human monocytic …

We developed a new approach that couples Southwestern blotting and mass spectrometry
to discover proteins that bind extracellular DNA (eDNA) in bacterial biofilms. Using …

Interbacterial antagonism and associated defensive strategies are both essential during
bacterial competition. The human gut symbiont Bacteroides fragilis secretes a ubiquitin …

Methicillin-resistant Staphylococcus aureus (MRSA) is an opportunistic pathogen and
responsible for causing life-threatening infections. The emergence of hypervirulent and …

Cytosolic metalloenzymes acquire metals from buffered intracellular pools. How exported
metalloenzymes are appropriately metalated is less clear. We provide evidence that TerC …

Pathogenic bacteria rely on secreted virulence factors to cause disease in susceptible hosts.
However, in Gram-positive bacteria, the mechanisms underlying secreted protein activation …

PpiD and YfgM are inner membrane proteins that are both composed of an N-terminal
transmembrane segment and a C-terminal periplasmic domain. Escherichia coli YfgM and …

Background PrsA is an extracytoplasmic folding catalyst essential in Bacillus subtilis.
Overexpression of the native PrsA from B. subtilis has repeatedly lead to increased amylase …

Abstract Background Enterococcus faecium and Staphylococcus aureus are the Gram-
positive pathogens of the ESKAPE group, known to represent a great threat to human health …