The microbiome–gut–brain axis in Parkinson disease—from basic research to the clinic
Evidence for a close bidirectional link between the brain and the gut has led to a paradigm
shift in neurology, especially in the case of Parkinson disease (PD), in which gastrointestinal …
shift in neurology, especially in the case of Parkinson disease (PD), in which gastrointestinal …
[HTML][HTML] Neuropathology of Alzheimer's disease
The key pathological hallmarks—extracellular plaques and intracellular neurofibrillary
tangles (NFT)—described by Alois Alzheimer in his seminal 1907 article are still central to …
tangles (NFT)—described by Alois Alzheimer in his seminal 1907 article are still central to …
Brain-first versus body-first Parkinson's disease: a multimodal imaging case-control study
Parkinson's disease is characterized by the presence of abnormal, intraneuronal α-
synuclein aggregates, which may propagate from cell-to-cell in a prion-like manner …
synuclein aggregates, which may propagate from cell-to-cell in a prion-like manner …
Gut microbiome dysbiosis across early Parkinson's disease, REM sleep behavior disorder and their first-degree relatives
The microbiota-gut-brain axis has been suggested to play an important role in Parkinson's
disease (PD). Here we performed a cross-sectional study to profile gut microbiota across …
disease (PD). Here we performed a cross-sectional study to profile gut microbiota across …
Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis
Abstract Development of central nervous system (CNS) is regulated by both intrinsic and
peripheral signals. Previous studies have suggested that environmental factors affect …
peripheral signals. Previous studies have suggested that environmental factors affect …
Gastrointestinal involvement in Parkinson's disease: pathophysiology, diagnosis, and management
T Warnecke, KH Schäfer, I Claus, K Del Tredici… - npj Parkinson's …, 2022 - nature.com
Growing evidence suggests an increasing significance for the extent of gastrointestinal tract
(GIT) dysfunction in Parkinson's disease (PD). Most patients suffer from GIT symptoms …
(GIT) dysfunction in Parkinson's disease (PD). Most patients suffer from GIT symptoms …
Fecal microbiota transplantation in neurological disorders
KEW Vendrik, RE Ooijevaar, PRC De Jong… - Frontiers in cellular …, 2020 - frontiersin.org
Background: Several studies suggested an important role of the gut microbiota in the
pathophysiology of neurological disorders, implying that alteration of the gut microbiota …
pathophysiology of neurological disorders, implying that alteration of the gut microbiota …
[HTML][HTML] Neuropathological evidence of body-first vs. brain-first Lewy body disease
Aggregation of alpha-synuclein into inclusion bodies, termed Lewy pathology, is a defining
feature of Parkinson's disease (PD) and Dementia with Lewy bodies (DLB). In the majority of …
feature of Parkinson's disease (PD) and Dementia with Lewy bodies (DLB). In the majority of …
Gut microbiota: a novel therapeutic target for Parkinson's disease
M Zhu, X Liu, Y Ye, X Yan, Y Cheng, L Zhao… - Frontiers in …, 2022 - frontiersin.org
Parkinson's disease (PD) is the second most common neurodegenerative disease
characterized by motor dysfunction. Growing evidence has demonstrated that gut dysbiosis …
characterized by motor dysfunction. Growing evidence has demonstrated that gut dysbiosis …
Motor and non-motor circuit disturbances in early Parkinson disease: which happens first?
For the last two decades, pathogenic concepts in Parkinson disease (PD) have revolved
around the toxicity and spread of α-synuclein. Thus, α-synuclein would follow caudo-rostral …
around the toxicity and spread of α-synuclein. Thus, α-synuclein would follow caudo-rostral …