Maternal immune activation and neuroinflammation in human neurodevelopmental disorders
Maternal health during pregnancy plays a major role in sha** health and disease risks in
the offspring. The maternal immune activation hypothesis proposes that inflammatory …
the offspring. The maternal immune activation hypothesis proposes that inflammatory …
Environmental influences on the epigenome: exposure-associated DNA methylation in human populations
EM Martin, RC Fry - Annual review of public health, 2018 - annualreviews.org
DNA methylation is the most well studied of the epigenetic regulators in relation to
environmental exposures. To date, numerous studies have detailed the manner by which …
environmental exposures. To date, numerous studies have detailed the manner by which …
[HTML][HTML] Knowledge gaps in understanding the metabolic and clinical effects of excess folates/folic acid: a summary, and perspectives, from an NIH workshop
Folate, an essential nutrient found naturally in foods in a reduced form, is present in dietary
supplements and fortified foods in an oxidized synthetic form (folic acid). There is …
supplements and fortified foods in an oxidized synthetic form (folic acid). There is …
Perinatal and early-life nutrition, epigenetics, and allergy
Epidemiological studies have shown a dramatic increase in the incidence and the
prevalence of allergic diseases over the last several decades. Environmental triggers …
prevalence of allergic diseases over the last several decades. Environmental triggers …
The Generation R Study: design and cohort update 2017
MN Kooijman, CJ Kruithof, CM van Duijn… - European journal of …, 2016 - Springer
Abstract The Generation R Study is a population-based prospective cohort study from fetal
life until adulthood. The study is designed to identify early environmental and genetic causes …
life until adulthood. The study is designed to identify early environmental and genetic causes …
Genetic contributions to autism spectrum disorder
Autism spectrum disorder (autism) is a heterogeneous group of neurodevelopmental
conditions characterized by early childhood-onset impairments in communication and social …
conditions characterized by early childhood-onset impairments in communication and social …
[HTML][HTML] Epigenome-wide meta-analysis of DNA methylation and childhood asthma
Background Epigenetic mechanisms, including methylation, can contribute to childhood
asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease …
asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease …
Social adversity and epigenetic aging: a multi-cohort study on socioeconomic differences in peripheral blood DNA methylation
Low socioeconomic status (SES) is associated with earlier onset of age-related chronic
conditions and reduced life-expectancy, but the underlying biomolecular mechanisms …
conditions and reduced life-expectancy, but the underlying biomolecular mechanisms …
Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
Birthweight is associated with health outcomes across the life course, DNA methylation may
be an underlying mechanism. In this meta-analysis of epigenome-wide association studies …
be an underlying mechanism. In this meta-analysis of epigenome-wide association studies …
Cohort profile: pregnancy and childhood epigenetics (PACE) consortium
Epigenetics refers to mitotically heritable changes to the DNA, which do not affect the DNA
sequence, but can influence its function. Currently, DNA methylation is the most studied …
sequence, but can influence its function. Currently, DNA methylation is the most studied …