Diverse origins of fibrinolytic enzymes: A comprehensive review

C Hazare, P Bhagwat, S Singh, S Pillai - Heliyon, 2024 - cell.com
Fibrinolytic enzymes cleave fibrin which plays a crucial role in thrombus formation which
otherwise leads to cardiovascular diseases. While different fibrinolytic enzymes have been …

Chemical modification of enzymes to improve biocatalytic performance

P Giri, AD Pagar, MD Patil, H Yun - Biotechnology Advances, 2021 - Elsevier
Improvement in intrinsic enzymatic features is in many instances a prerequisite for the
scalable applicability of many industrially important biocatalysts. To this end, various …

Microbial fibrinolytic enzymes as anti-thrombotics: production, characterisation and prodigious biopharmaceutical applications

C Sharma, A Osmolovskiy, R Singh - Pharmaceutics, 2021 - mdpi.com
Cardiac disorders such as acute myocardial infarction, embolism and stroke are primarily
attributed to excessive fibrin accumulation in the blood vessels, usually consequential in …

Marine microbial fibrinolytic enzymes: an overview of source, production, biochemical properties and thrombolytic activity

N Barzkar, ST Jahromi, F Vianello - Marine Drugs, 2022 - mdpi.com
Cardiovascular diseases (CVDs) have emerged as a major threat to global health resulting
in a decrease in life expectancy with respect to humans. Thrombosis is one of the foremost …

Purification, physicochemical properties, and statistical optimization of fibrinolytic enzymes especially from fermented foods: A comprehensive review

AMM Ali, SCB Bavisetty - International Journal of Biological …, 2020 - Elsevier
Fibrinolytic enzymes are proteases responsible for cleavage of fibrin mesh in thrombus clots,
which are the primary causative agents in cardiovascular diseases. Develo** safe …

[HTML][HTML] Serratiopeptidase: an integrated view of multifaceted therapeutic enzyme

SR Nair - Biomolecules, 2022 - mdpi.com
Microbial products have been used for the treatment of different diseases for many centuries.
The serratiopeptidase enzyme provides a new hope for COVID-19-infected patients …

[HTML][HTML] Purification and Characterization of a Fibrinolytic Enzyme from Marine Bacillus velezensis Z01 and Assessment of Its Therapeutic Efficacy In Vivo

Y Zhou, H Chen, B Yu, G Chen, Z Liang - Microorganisms, 2022 - mdpi.com
Fibrinolytic enzymes are the most effective agents for the treatment of thrombotic diseases.
In the present study, we purified and characterized an extracellular fibrinolytic serine …

[HTML][HTML] Biochemical characterization of immobilized recombinant subtilisin and synthesis and functional characterization of recombinant subtilisin capped silver and …

SS Shettar, ZK Bagewadi, TMY Khan… - Saudi Journal of …, 2024 - Elsevier
This pioneering research explores the transformative potential of recombinant subtilisin,
emphasizing its strategic immobilization and nanoparticle synthesis to elevate both stability …

Purification, characterization, and chemical modification of Bacillus velezensis SN-14 fibrinolytic enzyme

M Lu, Z Gao, S **ng, J Long, C Li, L He… - International Journal of …, 2021 - Elsevier
Fermented bean foods are a crucial source of fibrinolytic enzymes. The presented study
aimed to purify, characterize, and chemically modify Bacillus velezensis SN-14 fibrinolytic …

[HTML][HTML] Opportunities for nanomaterials in enzyme therapy

B Torres-Herrero, I Armenia, C Ortiz… - Journal of Controlled …, 2024 - Elsevier
In recent years, enzyme therapy strategies have rapidly evolved to catalyze essential
biochemical reactions with therapeutic potential. These approaches hold particular promise …