Ionizing radiation interacts with the immune system in many ways with a multiplicity that
mirrors the complexity of the immune system itself: namely the need to maintain a delicate …

Normal-tissue adverse effects following radiotherapy are common and significantly affect
quality of life. These effects cannot be accounted for by dosimetric, treatment, or …

Background and purpose This study was designed to identify common single nucleotide
polymorphisms (SNPs) associated with toxicity 2 years after radiotherapy. Materials and …

There is increasing evidence supporting the role of genetic variants in the development of
radiation-induced toxicity. However, previous candidate gene association studies failed to …

Purpose Several small studies have indicated that the ATM rs1801516 SNP is associated
with risk of normal tissue toxicity after radiotherapy. However, the findings have not been …

Radiogenomics designates a scientific field that addresses possible associations between
genetic germline alterations and normal tissue toxicity after radiotherapy. The ultimate aim of …

Adverse reactions in normal tissue after radiotherapy (RT) limit the dose that can be given to
tumour cells. Since 80% of individual variation in clinical response is estimated to be caused …

A workshop entitled “Radiation-Induced Fibrosis: Mechanisms and Opportunities to
Mitigate”(held in Rockville, MD, September 19, 2016) was organized by the Radiation …

Purpose To identify single-nucleotide polymorphisms (SNPs) in oxidative stress–related
genes associated with risk of late toxicities in breast cancer patients receiving radiation …

In 1936, Holthusen theorized the probability of achieving tumor control and of develo**
normal tissue complications after radiotherapy as a function of radiation dose. This concept …