Permanent disabilities following CNS injuries result from the failure of injured axons to
regenerate and rebuild functional connections with their original targets. By contrast, injury …

After an injury in the adult mammalian central nervous system (CNS), lesioned axons fail to
regenerate. This failure to regenerate contrasts with axons' remarkable potential to grow …

Highlights•Growth cone formation requires a precise actin and microtubule organization.•
Modulating cytoskeleton stability affects growth cone formation and axon elongation.• …

We generated a knockout mouse for the neuronal-specific β-tubulin isoform Tubb3 to
investigate its role in nervous system formation and maintenance. Tubb3−/− mice have no …

Motor-cargo recruitment to microtubules is often the rate-limiting step of intracellular
transport, and defects in this recruitment can cause neurodegenerative disease. Here, we …

Recent observations related to the structure of the cytoskeleton in neurons and novel
cytoskeletal abnormalities involved in the pathophysiology of some neurological diseases …

Microtubules (MTs) are an essential component of the neuronal cytoskeleton; they are
involved in various aspects of neuron development, maintenance, and functions including …

Microtubules (MTs) mediate various cellular functions such as structural support,
chromosome segregation, and intracellular transport. To achieve this, the pivotal properties …

After a dorsal root crush injury, centrally-projecting sensory axons fail to regenerate across
the dorsal root entry zone (DREZ) to extend into the spinal cord. We find that chemogenetic …

Abstract α-Tubulin detyrosination, largely catalyzed by vasohibins, is involved in many
microtubule (MT)-related cellular events. In this study, we identified a core heterodimeric …