Preclinical models of human disease provide powerful tools for therapeutic discovery but
have limitations. This problem is especially apparent in the field of acute kidney injury (AKI) …

Phosphodiesterase type 5 (PDE5) is pivotal in cellular signalling, regulating cyclic
guanosine monophosphate (cGMP) levels crucial for smooth muscle relaxation and …

Sildenafil, approved two decades ago, is the inhibitor of phosphodiesterase 5 (PDE5). First
of all, it was designated for angina pectoris, but soon it showed a wonderful efficacy in …

Multifaceted cellular pathways exhibit a crucial role in the preservation of homeostasis at the
molecular, cellular, and organism levels. One of the most important of these protective …

While extensive research using animal models has improved the understanding of acute
kidney injury (AKI), this knowledge has not been translated into effective treatments. Many …

Acute kidney injury (AKI) is associated with increased morbidity, prolonged hospitalization,
and mortality, especially in high risk patients. Phosphodiesterase 5 inhibitors (PDE5Is) …

Abstract Aims Ischemia/reperfusion (I/R) occurs in renal artery stenosis, partial nephrectomy
and most commonly during kidney transplantation. It brings serious consequences such as …

The kidneys are vital organs that play an important role in removing waste materials from the
blood, electrolyte balance, blood pressure regulation, and red blood cell genesis. Kidney …

Objective The aim of study was to investigate the effect of avanafil, a second-generation
phosphodiesterase-5 (PDE5) inhibitor, on cerebral ischemia reperfusion (CI/R) model …

Renoprotective effect of carbamylated darbepoetin and udenafil in ischemia-reperfusion of rat
kidney due to the effect of precon Page 1 Renoprotective effect of carbamylated darbepoetin …