Prostate cancer (PCa) has been known as the most prevalent cancer disease and the
second leading cause of cancer mortality in men almost all over the globe. There is an …

Liver metastasis (LM) confers poor survival and therapy resistance across cancer types, but
the mechanisms of liver-metastatic organotropism remain unknown. Here, through in vivo …

Genetic manipulations and pharmaceutical interventions to disturb lipid metabolism
homeostasis have emerged as an attractive approach for the management of cancer …

Membrane trafficking, a fundamental cellular process encompassing the transport of
molecules to specific organelles, endocytosis at the plasma membrane and protein …

Phosphoinositides serve as essential players in numerous biological activities and are
critical for overall cellular function. Due to their complex chemical structures, localization …

Although early prostate cancer depends on the androgen receptor signaling pathway, which
is predominant in luminal cells, there is much to be understood about the contribution of …

Acute lymphoblastic leukemia (ALL), a complex malignancy, displays varying expression
profiles of PIP4K2-related genes in adult patients. While PIP4K2A expression is elevated in …

Cancer cells, which divide indefinitely and without control, are frequently exposed to various
stress factors but manage to adapt and survive. The mechanisms by which cancer cells …

Alternative engineering approaches have led the design of implants with controlled physical
features to minimize adverse effects in biological tissues. Similar efforts have focused on …

The phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are therapeutic targets for
diseases such as cancer, neurodegeneration and immunological disorders as they are key …