Next-generation sequencing: insights to advance clinical investigations of the microbiome

CR Wensel, JL Pluznick, SL Salzberg, CL Sears - The Journal of clinical …, 2022 - jci.org
Next-generation sequencing (NGS) technology has advanced our understanding of the
human microbiome by allowing for the discovery and characterization of unculturable …

Unveiling microbial diversity: harnessing long-read sequencing technology

DP Agustinho, Y Fu, VK Menon, GA Metcalf… - Nature …, 2024 - nature.com
Long-read sequencing has recently transformed metagenomics, enhancing strain-level
pathogen characterization, enabling accurate and complete metagenome-assembled …

[HTML][HTML] Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer

A Fu, B Yao, T Dong, Y Chen, J Yao, Y Liu, H Li, H Bai… - Cell, 2022 - cell.com
Tumor-resident intracellular microbiota is an emerging tumor component that has been
documented for a variety of cancer types with unclear biological functions. Here, we …

Killing tumor-associated bacteria with a liposomal antibiotic generates neoantigens that induce anti-tumor immune responses

M Wang, B Rousseau, K Qiu, G Huang, Y Zhang… - Nature …, 2024 - nature.com
Increasing evidence implicates the tumor microbiota as a factor that can influence cancer
progression. In patients with colorectal cancer (CRC), we found that pre-resection antibiotics …

Bifidobacterium species associated with breastfeeding produce aromatic lactic acids in the infant gut

MF Laursen, M Sakanaka, N von Burg, U Mörbe… - Nature …, 2021 - nature.com
Breastfeeding profoundly shapes the infant gut microbiota, which is critical for early life
immune development, and the gut microbiota can impact host physiology in various ways …

Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course

X Zhou, R Baumann, X Gao, M Mendoza, S Singh… - Cell, 2022 - cell.com
Changes in gut microbiota have been associated with several diseases. Here, the
International Multiple Sclerosis Microbiome Study (iMSMS) studied the gut microbiome of …

Microplastics change soil properties, heavy metal availability and bacterial community in a Pb-Zn-contaminated soil

X Feng, Q Wang, Y Sun, S Zhang, F Wang - Journal of Hazardous materials, 2022 - Elsevier
Microplastics (MPs) co-occur widely with diverse contaminants in soils. However, few data
are available on their impacts on soil chemical and microbial properties of heavy metal …

Defining and quantifying the core microbiome: challenges and prospects

AT Neu, EE Allen, K Roy - Proceedings of the National Academy of …, 2021 - pnas.org
The term “core microbiome” has become widely used in microbial ecology over the last
decade. Broadly, the core microbiome refers to any set of microbial taxa, or the genomic and …

Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients

EN Baruch, I Youngster, G Ben-Betzalel, R Ortenberg… - Science, 2021 - science.org
The gut microbiome has been shown to influence the response of tumors to anti–PD-1
(programmed cell death–1) immunotherapy in preclinical mouse models and observational …

Low shifts in salinity determined assembly processes and network stability of microeukaryotic plankton communities in a subtropical urban reservoir

Y Mo, F Peng, X Gao, P **ao, R Logares, E Jeppesen… - Microbiome, 2021 - Springer
Background Freshwater salinization may result in significant changes of microbial
community composition and diversity, with implications for ecosystem processes and …