Plight of CORMs: The unreliability of four commercially available CO-releasing molecules, CORM-2, CORM-3, CORM-A1, and CORM-401, in studying CO biology

N Bauer, Z Yuan, X Yang, B Wang - Biochemical Pharmacology, 2023 - Elsevier
Carbon monoxide (CO) is an endogenously produced gaseous signaling molecule with
demonstrated pharmacological effects. In studying CO biology, three delivery forms have …

Chemiluminescent probes in cancer biology

R Blau, O Shelef, D Shabat… - Nature Reviews …, 2023 - nature.com
Optical imaging technologies that use fluorescence and chemiluminescence probes allow
the real-time detection of biological activity in the context of location, time and environment …

External stimuli-responsive gasotransmitter prodrugs: Chemistry and spatiotemporal release

X Ji, Z Zhong - Journal of Controlled Release, 2022 - Elsevier
Gasotransmitters like nitric oxide, carbon monoxide, and hydrogen sulfide with unique
pleiotropic pharmacological effects in mammals are an emerging therapeutic modality for …

Reactive oxygen species-activated metal-free carbon monoxide prodrugs for targeted cancer treatment

Z Li, Y Wang, M Liu, Y Pan, Z Ni, Q Min… - Journal of Medicinal …, 2023 - ACS Publications
Carbon monoxide has shown promise as a therapeutic agent against cancers. Reactive
oxygen species (ROS)-activated CO prodrugs are highly demanded for targeted cancer …

Reassessing CORM-A1: redox chemistry and idiosyncratic CO-releasing characteristics of the widely used carbon monoxide donor

N Bauer, X Yang, Z Yuan, B Wang - Chemical Science, 2023 - pubs.rsc.org
Carbon monoxide (CO) is an endogenous signaling molecule with demonstrated ability to
modulate immune responses and to engage key components of the circadian clock. Further …

Carbon monoxide therapy: a promising strategy for cancer

J Chai, J Zhu, Y Tian, K Yang, J Luan… - Journal of Materials …, 2023 - pubs.rsc.org
Cancer is one of the acute life-threatening diseases endangering the whole of humanity.
The treatment modalities for cancer are various. However, in most cases, a single treatment …

Dual-Mode Reactive Oxygen Species-Stimulated Carbon Monoxide Release for Synergistic Photodynamic and Gas Tumor Therapy

Y Yu, L Zhang, H Jia, C Ji, Y Liu, Z Zhao, C Dai… - ACS …, 2024 - ACS Publications
Controllable carbon monoxide (CO) release simulated by light-generated reactive oxygen
species (ROS) represents a promising approach for cancer therapy but is hampered by low …

Paclitaxel prodrug nanoparticles boost antitumor efficacy via hitchhiking of human serum albumin

S Lu, S Zhou, X **ang, B Zhang, Z Xu, Q Pei… - Journal of Colloid and …, 2025 - Elsevier
Improving drug delivery efficacy is the key point for enhancing the therapeutic index of
medicines. Herein, we report fatty chain conjugated paclitaxel (PTX) prodrugs with a …

Bioorthogonal Bond Cleavage Chemistry for On-demand Prodrug Activation: Opportunities and Challenges

Q Min, X Ji - Journal of Medicinal Chemistry, 2023 - ACS Publications
Time-and space-resolved drug delivery is highly demanded for cancer treatment, which,
however, can barely be achieved with a traditional prodrug strategy. In recent years, the …

Recent applications of phase-change materials in tumor therapy and theranostics

M He, Y Wang, D Li, M Zhang, T Wang, F Zhi, X Ji… - Biomaterials …, 2023 - Elsevier
Phase-change materials (PCMs) are a type of special material which can store and release
a large amount of thermal energy without any significant temperature change. They are …