Plight of CORMs: The unreliability of four commercially available CO-releasing molecules, CORM-2, CORM-3, CORM-A1, and CORM-401, in studying CO biology
Carbon monoxide (CO) is an endogenously produced gaseous signaling molecule with
demonstrated pharmacological effects. In studying CO biology, three delivery forms have …
demonstrated pharmacological effects. In studying CO biology, three delivery forms have …
Chemiluminescent probes in cancer biology
Optical imaging technologies that use fluorescence and chemiluminescence probes allow
the real-time detection of biological activity in the context of location, time and environment …
the real-time detection of biological activity in the context of location, time and environment …
External stimuli-responsive gasotransmitter prodrugs: Chemistry and spatiotemporal release
Gasotransmitters like nitric oxide, carbon monoxide, and hydrogen sulfide with unique
pleiotropic pharmacological effects in mammals are an emerging therapeutic modality for …
pleiotropic pharmacological effects in mammals are an emerging therapeutic modality for …
Reactive oxygen species-activated metal-free carbon monoxide prodrugs for targeted cancer treatment
Z Li, Y Wang, M Liu, Y Pan, Z Ni, Q Min… - Journal of Medicinal …, 2023 - ACS Publications
Carbon monoxide has shown promise as a therapeutic agent against cancers. Reactive
oxygen species (ROS)-activated CO prodrugs are highly demanded for targeted cancer …
oxygen species (ROS)-activated CO prodrugs are highly demanded for targeted cancer …
Reassessing CORM-A1: redox chemistry and idiosyncratic CO-releasing characteristics of the widely used carbon monoxide donor
Carbon monoxide (CO) is an endogenous signaling molecule with demonstrated ability to
modulate immune responses and to engage key components of the circadian clock. Further …
modulate immune responses and to engage key components of the circadian clock. Further …
Carbon monoxide therapy: a promising strategy for cancer
J Chai, J Zhu, Y Tian, K Yang, J Luan… - Journal of Materials …, 2023 - pubs.rsc.org
Cancer is one of the acute life-threatening diseases endangering the whole of humanity.
The treatment modalities for cancer are various. However, in most cases, a single treatment …
The treatment modalities for cancer are various. However, in most cases, a single treatment …
Dual-Mode Reactive Oxygen Species-Stimulated Carbon Monoxide Release for Synergistic Photodynamic and Gas Tumor Therapy
Y Yu, L Zhang, H Jia, C Ji, Y Liu, Z Zhao, C Dai… - ACS …, 2024 - ACS Publications
Controllable carbon monoxide (CO) release simulated by light-generated reactive oxygen
species (ROS) represents a promising approach for cancer therapy but is hampered by low …
species (ROS) represents a promising approach for cancer therapy but is hampered by low …
Paclitaxel prodrug nanoparticles boost antitumor efficacy via hitchhiking of human serum albumin
S Lu, S Zhou, X **ang, B Zhang, Z Xu, Q Pei… - Journal of Colloid and …, 2025 - Elsevier
Improving drug delivery efficacy is the key point for enhancing the therapeutic index of
medicines. Herein, we report fatty chain conjugated paclitaxel (PTX) prodrugs with a …
medicines. Herein, we report fatty chain conjugated paclitaxel (PTX) prodrugs with a …
Bioorthogonal Bond Cleavage Chemistry for On-demand Prodrug Activation: Opportunities and Challenges
Q Min, X Ji - Journal of Medicinal Chemistry, 2023 - ACS Publications
Time-and space-resolved drug delivery is highly demanded for cancer treatment, which,
however, can barely be achieved with a traditional prodrug strategy. In recent years, the …
however, can barely be achieved with a traditional prodrug strategy. In recent years, the …
Recent applications of phase-change materials in tumor therapy and theranostics
M He, Y Wang, D Li, M Zhang, T Wang, F Zhi, X Ji… - Biomaterials …, 2023 - Elsevier
Phase-change materials (PCMs) are a type of special material which can store and release
a large amount of thermal energy without any significant temperature change. They are …
a large amount of thermal energy without any significant temperature change. They are …