[HTML][HTML] The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth
Cancers represent complex ecosystems comprising tumor cells and a multitude of non-
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …
The local microenvironment drives activation of neutrophils in human brain tumors
Neutrophils are abundant immune cells in the circulation and frequently infiltrate tumors in
substantial numbers. However, their precise functions in different cancer types remain …
substantial numbers. However, their precise functions in different cancer types remain …
NETosis: sculpting tumor metastasis and immunotherapy
Y Hu, H Wang, Y Liu - Immunological Reviews, 2024 - Wiley Online Library
The process of neutrophil extracellular traps (NETs) formation, called NETosis, is a peculiar
death modality of neutrophils, which was first observed as an immune response against …
death modality of neutrophils, which was first observed as an immune response against …
Interrogation of endothelial and mural cells in brain metastasis reveals key immune-regulatory mechanisms
L Bejarano, A Kauzlaric, E Lamprou, J Lourenco… - Cancer cell, 2024 - cell.com
Brain metastasis (BrM) is a common malignancy, predominantly originating from lung,
melanoma, and breast cancers. The vasculature is a key component of the BrM tumor …
melanoma, and breast cancers. The vasculature is a key component of the BrM tumor …
Distinct tumor architectures and microenvironments for the initiation of breast cancer metastasis in the brain
Brain metastasis, a serious complication of cancer, hinges on the initial survival,
microenvironment adaptation, and outgrowth of disseminated cancer cells. To understand …
microenvironment adaptation, and outgrowth of disseminated cancer cells. To understand …
Genomic analysis and clinical correlations of non-small cell lung cancer brain metastasis
Up to 50% of patients with non-small cell lung cancer (NSCLC) develop brain metastasis
(BM), yet the study of BM genomics has been limited by tissue access, incomplete clinical …
(BM), yet the study of BM genomics has been limited by tissue access, incomplete clinical …
Harnessing immunotherapy for brain metastases: insights into tumor–brain microenvironment interactions and emerging treatment modalities
D Zhou, Z Gong, D Wu, C Ma, L Hou, X Niu… - Journal of Hematology & …, 2023 - Springer
Brain metastases signify a deleterious milestone in the progression of several advanced
cancers, predominantly originating from lung, breast and melanoma malignancies, with a …
cancers, predominantly originating from lung, breast and melanoma malignancies, with a …
Utilizing human cerebral organoids to model breast cancer brain metastasis in culture
Background Metastasis, the spread, and growth of malignant cells at secondary sites within
a patient's body, accounts for over 90% of cancer-related mortality. Breast cancer is the most …
a patient's body, accounts for over 90% of cancer-related mortality. Breast cancer is the most …
Embracing diversity: macrophage complexity in cancer
Macrophages are myeloid cells that receive, integrate, and respond to tumoral cues. Tumors
evolve and are shaped by macrophages, with tumor-associated macrophage (TAM)-tumor …
evolve and are shaped by macrophages, with tumor-associated macrophage (TAM)-tumor …
Stereotactic radiosurgery and stereotactic fractionated radiotherapy in the management of brain metastases
S Benkhaled, L Schiappacasse, A Awde, R Kinj - Cancers, 2024 - mdpi.com
Simple Summary The management of brain metastases (BM) is a major issue in cancer
treatment, and one of the main goals of BM treatment is to achieve effective disease control …
treatment, and one of the main goals of BM treatment is to achieve effective disease control …