Anaphylaxis is a severe systemic hypersensitivity reaction that is rapid in onset;
characterized by life-threatening airway, breathing, and/or circulatory problems; and usually …

Food allergies are increasing in prevalence at a higher rate than can be explained by
genetic factors, suggesting a role for as yet unidentified environmental factors. In this review …

Experimental IgE-mediated food allergy depends on intestinal anaphylaxis driven by
interleukin-9 (IL-9). However, the primary cellular source of IL-9 and the mechanisms …

Background Food-mediated allergic reactions have emerged as a major health problem.
The underlying mechanisms that promote uncontrolled type 2 immune responses to dietary …

Food allergies represent an increasingly prevalent human health problem, and therapeutic
options remain limited, with avoidance being mainstay, despite its adverse effects on quality …

Food allergy is a rapidly growing public health concern because of its increasing prevalence
and life-threatening potential. Animal models of food allergy have emerged as a tool for …

The roles of mast cells in health and disease remain incompletely understood. While the
evidence that mast cells are critical effector cells in IgE-dependent anaphylaxis and other …

Mast cells (MCs) are cells of hematopoietic origin that normally reside in mucosal tissues,
often near epithelial cells, glands, smooth muscle cells, and nerves. Best known for their …

Background Treatments to reverse peanut allergy remain elusive. Current clinical
approaches using peanut oral/sublingual immunotherapy are promising, but concerns about …

Background Studies with c-kit mutant mast cell (MC)–deficient mice and antibody-mediated
depletion of basophils suggest that both MCs and basophils can contribute to peanut …