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Sexual dimorphism in colon cancer
A higher incidence of colorectal cancer (CRC) is found in males compared to females.
Young women (18–44 years) with CRC have a better survival outcome compared to men of …
Young women (18–44 years) with CRC have a better survival outcome compared to men of …
Estrogen receptor alpha and beta in health and disease
Estrogen receptors alpha (ERα) and beta (ERβ) are transcription factors that are involved in
the regulation of many complex physiological processes in humans. Abnormal ER signaling …
the regulation of many complex physiological processes in humans. Abnormal ER signaling …
Insufficient antibody validation challenges oestrogen receptor beta research
The discovery of oestrogen receptor β (ERβ/ESR2) was a landmark discovery. Its reported
expression and homology with breast cancer pharmacological target ERα (ESR1) raised …
expression and homology with breast cancer pharmacological target ERα (ESR1) raised …
Molecular pathways: estrogen pathway in colorectal cancer
Worldwide, colorectal cancer has a higher incidence rate in men than in women, suggesting
a protective role for sex hormones in the development of the disease. Preclinical data …
a protective role for sex hormones in the development of the disease. Preclinical data …
Estrogen receptors and their implications in colorectal carcinogenesis
Upon binding their cognate receptors, ERα (ESR1) and ERβ (ESR2), estrogens activate
intracellular signaling cascades that have important consequences for cellular behavior …
intracellular signaling cascades that have important consequences for cellular behavior …
Pathway analysis of genomic data: concepts, methods, and prospects for future development
Genome-wide data sets are increasingly being used to identify biological pathways and
networks underlying complex diseases. In particular, analyzing genomic data through sets …
networks underlying complex diseases. In particular, analyzing genomic data through sets …
Colitis‐induced colorectal cancer and intestinal epithelial estrogen receptor beta impact gut microbiota diversity
Chronic inflammation of the colon (colitis) is a risk factor for colorectal cancer (CRC).
Hormone‐replacement therapy reduces CRC incidences, and the estrogen receptor beta …
Hormone‐replacement therapy reduces CRC incidences, and the estrogen receptor beta …
Estrogen receptor beta as target for colorectal cancer prevention
Colorectal cancer (CRC) is a leading cause of death in the United States. Despite its slow
development and the capacity for early diagnosis, current preventive approaches are not …
development and the capacity for early diagnosis, current preventive approaches are not …
The role of the tumor microenvironment in colorectal cancer and the potential therapeutic approaches
Background Colorectal cancer (CRC) with a high prevalence is recognized as the fourth
most common cause of cancer‐related death globally. Over the past decade, there has been …
most common cause of cancer‐related death globally. Over the past decade, there has been …
[HTML][HTML] Estrogen suppresses hepatocellular carcinoma cells through ERβ-mediated upregulation of the NLRP3 inflammasome
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. The
incidence of HCC is strikingly higher in males than in females. The remarkable gender …
incidence of HCC is strikingly higher in males than in females. The remarkable gender …