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Tight junction proteins occludin and ZO‐1 as regulators of epithelial proliferation and survival
WT Kuo, MA Odenwald, JR Turner… - Annals of the New York …, 2022 - Wiley Online Library
Epithelial cells are the first line of mucosal defense. In the intestine, a single layer of
epithelial cells must establish a selectively permeable barrier that supports nutrient …
epithelial cells must establish a selectively permeable barrier that supports nutrient …
Breakthroughs in hepatitis C research: from discovery to cure
MP Manns, B Maasoumy - Nature reviews Gastroenterology & …, 2022 - nature.com
In the 1970s, an unknown virus was suspected for documented cases of transfusion-
associated hepatitis, a phenomenon called non-A, non-B hepatitis. In 1989, the infectious …
associated hepatitis, a phenomenon called non-A, non-B hepatitis. In 1989, the infectious …
Inflammation and the intestinal barrier: leukocyte–epithelial cell interactions, cell junction remodeling, and mucosal repair
The intestinal tract is lined by a single layer of columnar epithelial cells that forms a dynamic,
permeable barrier allowing for selective absorption of nutrients, while restricting access to …
permeable barrier allowing for selective absorption of nutrients, while restricting access to …
The mammalian blood-testis barrier: its biology and regulation
DD Mruk, CY Cheng - Endocrine reviews, 2015 - academic.oup.com
Spermatogenesis is the cellular process by which spermatogonia develop into mature
spermatids within seminiferous tubules, the functional unit of the mammalian testis, under …
spermatids within seminiferous tubules, the functional unit of the mammalian testis, under …
Tight junction proteins in gastrointestinal and liver disease
MB Zeisel, P Dhawan, TF Baumert - Gut, 2019 - gut.bmj.com
Over the past two decades a growing body of evidence has demonstrated an important role
of tight junction (TJ) proteins in the physiology and disease biology of GI and liver disease …
of tight junction (TJ) proteins in the physiology and disease biology of GI and liver disease …
Host-directed antiviral therapy
N Kumar, S Sharma, R Kumar, BN Tripathi… - Clinical microbiology …, 2020 - journals.asm.org
Antiviral drugs have traditionally been developed by directly targeting essential viral
components. However, this strategy often fails due to the rapid generation of drug-resistant …
components. However, this strategy often fails due to the rapid generation of drug-resistant …
Antiviral nanoparticles for sanitizing surfaces: A roadmap to self-sterilizing against COVID-19
Nanoparticles provide new opportunities in merging therapeutics and new materials, with
current research efforts just beginning to scratch the surface of their diverse benefits and …
current research efforts just beginning to scratch the surface of their diverse benefits and …
A diverse range of gene products are effectors of the type I interferon antiviral response
JW Schoggins, SJ Wilson, M Panis, MY Murphy… - Nature, 2011 - nature.com
The type I interferon response protects cells against invading viral pathogens. The cellular
factors that mediate this defence are the products of interferon-stimulated genes (ISGs) …
factors that mediate this defence are the products of interferon-stimulated genes (ISGs) …
Viral quasispecies evolution
Evolution of RNA viruses occurs through disequilibria of collections of closely related mutant
spectra or mutant clouds termed viral quasispecies. Here we review the origin of the …
spectra or mutant clouds termed viral quasispecies. Here we review the origin of the …
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies
TKH Scheel, CM Rice - Nature medicine, 2013 - nature.com
More than two decades of intense research has provided a detailed understanding of
hepatitis C virus (HCV), which chronically infects 2% of the world's population. This effort has …
hepatitis C virus (HCV), which chronically infects 2% of the world's population. This effort has …