Mitochondrial metabolism and cancer
Glycolysis has long been considered as the major metabolic process for energy production
and anabolic growth in cancer cells. Although such a view has been instrumental for the …
and anabolic growth in cancer cells. Although such a view has been instrumental for the …
The chaperone TRAP1 as a modulator of the mitochondrial adaptations in cancer cells
Mitochondria can receive, integrate, and transmit a variety of signals to shape many
biochemical activities of the cell. In the process of tumor onset and growth, mitochondria …
biochemical activities of the cell. In the process of tumor onset and growth, mitochondria …
Hexokinase 2 displacement from mitochondria‐associated membranes prompts Ca2+‐dependent death of cancer cells
Cancer cells undergo changes in metabolic and survival pathways that increase their
malignancy. Isoform 2 of the glycolytic enzyme hexokinase (HK 2) enhances both glucose …
malignancy. Isoform 2 of the glycolytic enzyme hexokinase (HK 2) enhances both glucose …
The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer
N Ghaddar, S Wang, B Woodvine… - Nature …, 2021 - nature.com
The integrated stress response (ISR) is an essential stress-support pathway increasingly
recognized as a determinant of tumorigenesis. Here we demonstrate that ISR is pivotal in …
recognized as a determinant of tumorigenesis. Here we demonstrate that ISR is pivotal in …
Rational design of allosteric and selective inhibitors of the molecular chaperone TRAP1
TRAP1 is the mitochondrial paralog of the heat shock protein 90 (HSP90) chaperone family.
Its activity as an energy metabolism regulator has important implications in cancer …
Its activity as an energy metabolism regulator has important implications in cancer …
The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis
Background The molecular chaperone TRAP1, the mitochondrial isoform of cytosolic
HSP90, remains poorly understood with respect to its pivotal role in the regulation of …
HSP90, remains poorly understood with respect to its pivotal role in the regulation of …
Mitochondrial functions and rare diseases
Mitochondria are dynamic cellular organelles responsible for a large variety of biochemical
processes as energy transduction, REDOX signaling, the biosynthesis of hormones and …
processes as energy transduction, REDOX signaling, the biosynthesis of hormones and …
The mitochondrial chaperone TRAP1 regulates F-ATP synthase channel formation
Binding of the mitochondrial chaperone TRAP1 to client proteins shapes bioenergetic and
proteostatic adaptations of cells, but the panel of TRAP1 clients is only partially defined …
proteostatic adaptations of cells, but the panel of TRAP1 clients is only partially defined …
Metabolic plasticity of tumor cell mitochondria
Mitochondria are dynamic organelles that exchange a multiplicity of signals with other cell
compartments, in order to finely adjust key biological routines to the fluctuating metabolic …
compartments, in order to finely adjust key biological routines to the fluctuating metabolic …
The Warburg effect and mitochondrial oxidative phosphorylation: Friends or foes?
MM Pinto, P Paumard, C Bouchez, S Ransac… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Cancer cells display an altered energy metabolism, which was proposed to be the root of
cancer. This early discovery was done by O. Warburg who conducted one of the first studies …
cancer. This early discovery was done by O. Warburg who conducted one of the first studies …