The review presents a detailed discussion of the evolving field studying interactions
between ionic liquids (ILs) and biological systems. Originating from molten salt electrolytes …

The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN) 1, OCTN2,
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …

The tailorable and often unique properties of ionic liquids (ILs) drive their implementation
into a broad variety of seminal technologies. The modular design of ILs allows in this context …

The kidney is a vital organ for the elimination of therapeutic drugs and their metabolites.
Renal drug transporters, which are primarily located in the renal proximal tubules, play an …

Creatinine is actively secreted across tubular epithelial cells via organic cation transporter 2
(OCT2) and multidrug and toxin extrusion 1 (MATE1). We previously showed that the …

Background The disposition of statins varies and involves both metabolizing enzymes and
transporters, making predictions of statin drug-drug interactions (DDIs) challenging …

Tenofovir disoproxil fumarate, the prodrug of nucleotide reverse transcriptase inhibitor
tenofovir, shows high efficacy and relatively low toxicity in HIV patients. However, long-term …

This study was a comprehensive analysis of metabolites in plasma and urine specimens
from subjects who received probenecid, a potent inhibitor of renal organic anion transporters …

In humans, creatinine is formed by a multistep process in liver and muscle and eliminated
via the kidney by a combination of glomerular filtration and active transport. Based on …

Organic cation transporter 1 (OCT1) plays a critical role in the hepatocellular uptake of
structurally diverse endogenous compounds and xenobiotics. Here we identified competitive …