Comparative Pathobiology of the Intestinal Protozoan Parasites Giardia lamblia, Entamoeba histolytica, and Cryptosporidium parvum

A Hemphill, N Müller, J Müller - Pathogens, 2019 - mdpi.com
Protozoan parasites can infect the human intestinal tract causing serious diseases. In the
following article, we focused on the three most prominent intestinal protozoan pathogens …

Pharmacology, toxicology, and metabolism of sennoside A, A medicinal plant-derived natural compound

J Le, H Ji, X Zhou, X Wei, Y Chen, Y Fu, Y Ma… - Frontiers in …, 2021 - frontiersin.org
Sennoside A (SA) is a natural dianthrone glycoside mainly from medicinal plants of Senna
and Rhubarb, and used as a folk traditional irritant laxative and slimming health food …

The pH‐responsive PacC transcription factor plays pivotal roles in virulence and patulin biosynthesis in Penicillium expansum

Y Chen, B Li, X Xu, Z Zhang… - Environmental …, 2018 - Wiley Online Library
The PacC (loss or reduction in p hosphatase ac tivity at acid but not at alkaline pH [Pac])
transcription factor regulates environmental adaptation, secondary metabolism and …

[HTML][HTML] Highly divergent mitochondrion-related organelles in anaerobic parasitic protozoa

T Makiuchi, T Nozaki - Biochimie, 2014 - Elsevier
The mitochondria have arisen as a consequence of endosymbiosis of an ancestral α-
proteobacterium with a methane-producing archae. The main function of the canonical …

[HTML][HTML] Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites

JS Pham, KL Dawson, KE Jackson, EE Lim… - International Journal for …, 2014 - Elsevier
Aminoacyl-tRNA synthetases are central enzymes in protein translation, providing the
charged tRNAs needed for appropriate construction of peptide chains. These enzymes have …

Trypanothione: a unique bis-glutathionyl derivative in trypanosomatids

B Manta, M Comini, A Medeiros, M Hugo… - … et Biophysica Acta (BBA …, 2013 - Elsevier
BACKGROUND: Trypanosomatids are early-diverging eukaryotes devoid of the major
disulfide reductases–glutathione reductase and thioredoxin reductase–that control thiol …

Mitosomes in Entamoeba histolytica contain a sulfate activation pathway

F Mi-Ichi, MA Yousuf… - Proceedings of the …, 2009 - National Acad Sciences
Hydrogenosomes and mitosomes are mitochondrion-related organelles in anaerobic/
microaerophilic eukaryotes with highly reduced and divergent functions. The full diversity of …

The globalization of traditional medicine in northern peru: from shamanism to molecules

RW Bussmann - Evidence‐Based Complementary and …, 2013 - Wiley Online Library
Northern Peru represents the center of the Andean “health axis,” with roots going back to
traditional practices of Cupisnique culture (1000 BC). For more than a decade of research …

Inhibitors of amino acids biosynthesis as antifungal agents

K Jastrzębowska, I Gabriel - Amino acids, 2015 - Springer
Fungal microorganisms, including the human pathogenic yeast and filamentous fungi, are
able to synthesize all proteinogenic amino acids, including nine that are essential for …

Control of Clostridium difficile physiopathology in response to cysteine availability

T Dubois, M Dancer-Thibonnier, M Monot… - Infection and …, 2016 - Am Soc Microbiol
The pathogenicity of Clostridium difficile is linked to its ability to produce two toxins: TcdA
and TcdB. The level of toxin synthesis is influenced by environmental signals, such as …