PIWI-interacting RNAs: small RNAs with big functions
In animals, PIWI-interacting RNAs (piRNAs) of 21–35 nucleotides in length silence
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …
ceRNA in cancer: possible functions and clinical implications
X Qi, DH Zhang, N Wu, JH **ao, X Wang… - Journal of medical …, 2015 - jmg.bmj.com
Competing endogenous RNAs (ceRNAs) are transcripts that can regulate each other at post-
transcription level by competing for shared miRNAs. CeRNA networks link the function of …
transcription level by competing for shared miRNAs. CeRNA networks link the function of …
The biochemical basis of microRNA targeting efficacy
INTRODUCTION MicroRNAs (miRNAs) are short RNAs that guide repression of mRNA
targets. Each miRNA associates with an Argonaute (AGO) protein to form a complex in …
targets. Each miRNA associates with an Argonaute (AGO) protein to form a complex in …
mirDIP 4.1—integrative database of human microRNA target predictions
MicroRNAs are important regulators of gene expression, achieved by binding to the gene to
be regulated. Even with modern high-throughput technologies, it is laborious and expensive …
be regulated. Even with modern high-throughput technologies, it is laborious and expensive …
Predicting effective microRNA target sites in mammalian mRNAs
MicroRNA targets are often recognized through pairing between the miRNA seed region
and complementary sites within target mRNAs, but not all of these canonical sites are …
and complementary sites within target mRNAs, but not all of these canonical sites are …
Sequence, structure, and context preferences of human RNA binding proteins
D Dominguez, P Freese, MS Alexis, A Su, M Hochman… - Molecular cell, 2018 - cell.com
RNA binding proteins (RBPs) orchestrate the production, processing, and function of
mRNAs. Here, we present the affinity landscapes of 78 human RBPs using an unbiased …
mRNAs. Here, we present the affinity landscapes of 78 human RBPs using an unbiased …
miRNA targets: from prediction tools to experimental validation
G Riolo, S Cantara, C Marzocchi, C Ricci - Methods and protocols, 2020 - mdpi.com
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression in both animals
and plants. By pairing to microRNA responsive elements (mREs) on target mRNAs, miRNAs …
and plants. By pairing to microRNA responsive elements (mREs) on target mRNAs, miRNAs …
tRNA fragments (tRFs) guide Ago to regulate gene expression post-transcriptionally in a Dicer-independent manner
tRNA related RNA fragments (tRFs), also known as tRNA-derived RNAs (tdRNAs), are
abundant small RNAs reported to be associated with Argonaute proteins, yet their function is …
abundant small RNAs reported to be associated with Argonaute proteins, yet their function is …
Diversifying microRNA sequence and function
MicroRNAs (miRNAs) regulate the expression of most genes in animals, but we are only
now beginning to understand how they are generated, assembled into functional complexes …
now beginning to understand how they are generated, assembled into functional complexes …
Identification and consequences of miRNA–target interactions—beyond repression of gene expression
Comparative genomics analyses and high-throughput experimental studies indicate that a
microRNA (miRNA) binds to hundreds of sites across the transcriptome. Although the …
microRNA (miRNA) binds to hundreds of sites across the transcriptome. Although the …