Soluble oligomers of amyloid β (Aβ) play a role in the memory impairment characteristic of
Alzheimer's disease. Acting as pathogenic ligands, Aβ oligomers bind to particular synapses …

Alterations in sensory processing constitute prominent symptoms of fragile X syndrome;
however, little is known about how disrupted synaptic and circuit development in sensory …

The metabotropic glutamate receptor subtype 5 (mGlu5) is a family C GPCR that has been
implicated in various neuronal processes and, consequently, in several CNS disorders. Over …

Sensory inputs triggered by external stimuli are projected into discrete arrays of neuronal
modules in the primary sensory cortex. This whisker‐to‐barrel pathway has gained in …

Monocular lid closure (MC) causes a profound shift in the ocular dominance (OD) of neurons
in primary visual cortex (V1). Anatomical studies in both cat and mouse V1 suggest that …

Exposure to early life stress leads to long‐term neurochemical and behavioral alterations.
Stress‐induced psychiatric disorders, such as depression, have recently been linked to …

Tuberous sclerosis is a developmental genetic disorder caused by mutations in TSC1, which
results in epilepsy, autism, and intellectual disability. The cause of these neurological …

Glutamatergic neurotransmission plays important roles in sensory map formation. The
absence of the group I metabotropic glutamate receptor 5 (mGluR5) leads to abnormal …

Fibroblast growth factors (FGFs) and FGF receptors (FGFRs) are known for their potent
effects on cell proliferation/differentiation and cortical patterning in the develo** brain …

The somatosensory cortex of many rodents, lagomorphs, and marsupials contains distinct
cytoarchitectonic features named “barrels” that reflect the pattern of large facial whiskers on …