Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis

AS Nagle, S Khare, AB Kumar, F Supek… - Chemical …, 2014 - ACS Publications
Leishmaniasis is a parasitic disease that presents four main clinical syndromes: cutaneous
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …

Scorpion venom: detriments and benefits

S Ahmadi, JM Knerr, L Argemi, KCF Bordon, MB Pucca… - Biomedicines, 2020 - mdpi.com
Scorpion venom may cause severe medical complications and untimely death if injected into
the human body. Neurotoxins are the main components of scorpion venom that are known to …

Bioactive peptides from scorpion venoms: therapeutic scaffolds and pharmacological tools

KP Muiruri, J Zhong, YAO Bing, LAI Ren… - Chinese Journal of …, 2023 - Elsevier
Evolution and natural selection have endowed animal venoms, including scorpion venoms,
with a wide range of pharmacological properties. Consequently, scorpions, their venoms …

Antimicrobial peptides: On future antiprotozoal and anthelminthic applications

K Nogrado, P Adisakwattana, O Reamtong - Acta Tropica, 2022 - Elsevier
Control and elimination of parasitic diseases are nowadays further complicated by
emergence of drug resistance. Drug resistance is a serious threat as there are not many …

Analogs of the scorpion venom peptide stigmurin: structural assessment, toxicity, and increased antimicrobial activity

AMS Parente, A Daniele-Silva, AA Furtado, MA Melo… - Toxins, 2018 - mdpi.com
Scorpion venom is a rich source of biologically active components and various peptides with
high-potential therapeutic use that have been characterized for their antimicrobial and …

Natural occurrence in venomous arthropods of antimicrobial peptides active against protozoan parasites

EF Sabia Junior, LFS Menezes, IFS de Araújo… - Toxins, 2019 - mdpi.com
Arthropoda is a phylum of invertebrates that has undergone remarkable evolutionary
radiation, with a wide range of venomous animals. Arthropod venom is a complex mixture of …

Scorpion venom (Odontobuthus doriae) induces apoptosis by depolarization of mitochondria and reduces S-phase population in human breast cancer cells (MCF-7)

J Zargan, S Umar, M Sajad, M Naime, S Ali, HA Khan - Toxicology in vitro, 2011 - Elsevier
Venom of some species of scorpions induces apoptosis and arrests proliferation in cancer
cells. This is an important property that can be harnessed and can lead to isolation of …

Scorpion (Odontobuthus doriae) venom induces apoptosis and inhibits DNA synthesis in human neuroblastoma cells

J Zargan, M Sajad, S Umar, M Naime, S Ali… - Molecular and cellular …, 2011 - Springer
Scorpion and its organs have been used to cure epilepsy, rheumatism, and male impotency
since medieval times. Scorpion venom which contains different compounds like enzyme and …

Scorpion (Androctonus crassicauda) venom limits growth of transformed cells (SH-SY5Y and MCF-7) by cytotoxicity and cell cycle arrest

J Zargan, M Sajad, S Umar, M Naime, S Ali… - … and molecular pathology, 2011 - Elsevier
The purpose of study was to examine the cytotoxic and anti-cancer properties along with
addressing the plausible pathway followed by scorpion venom to reduce cell viability in SH …

Systematic review of antiprotozoal potential of antimicrobial peptides

FA Santos, GS Cruz, FA Vieira, BRS Queiroz… - Acta Tropica, 2022 - Elsevier
Protozoa is a group of microorganisms that cause neglected tropical diseases, such as
malaria, Chagas disease, and Leishmaniasis. Due to the growing demand for new …