Engineering functional human cardiac tissue that mimics the native adult morphological and
functional phenotype has been a long held objective. In the last 5 years, the field of cardiac …

Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …

Objective Dravet syndrome is a severe form of intractable pediatric epilepsy with a high
incidence of SUDEP: S udden U nexpected D eath in epilepsy. Cardiac arrhythmias are a …

Voltage-gated sodium (Nav) channels are intrinsic plasma membrane proteins that initiate
the action potential in electrically excitable cells. They are a major focus of research in …

The vertebrate sodium (Na v) channel is composed of an ion-conducting α subunit and
associated β subunits. Here, we report the crystal structure of the human β3 subunit …

In cardiac myocytes, the voltage‐gated sodium channel NaV1. 5 opens in response to
membrane depolarisation and initiates the action potential. The NaV1. 5 channel is typically …

Mutations in voltage-gated Na+ channels have been linked to several channelopathies
leading to a wide variety of diseases including cardiac arrhythmias, epilepsy, and myotonia …

Cardiac myocyte contraction is initiated by a set of intricately orchestrated electrical
impulses, collectively known as action potentials (APs). Voltage-gated sodium channels …

Nav1. 5 is the predominant cardiac sodium channel subtype, encoded by the SCN5A gene,
which is involved in the initiation and conduction of action potentials throughout the heart …

Cardiovascular disease remains the single largest cause of natural death in the United
States, with a significant cause of mortality associated with cardiac arrhythmias. Presently …