Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

Connexins are widely distributed proteins in the body that are crucially important for heart
and brain functions. Six connexin subunits form a connexon or hemichannel in the plasma …

Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …

Protein phosphorylation is a major control mechanism of a wide range of physiological
processes and plays an important role in cardiac pathophysiology. Serine/threonine protein …

Rationale: Atrial fibrillation (AF) is the most common arrhythmia, and advanced age is an
inevitable and predominant AF risk factor. However, the mechanisms that couple aging and …

Reversible protein phosphorylation is central to a variety of cardiac processes including
excitation-contraction coupling, Ca 2+ handling, cell metabolism, myofilament regulation …

Kinase/phosphatase balance governs cardiac excitability in health and disease. Although
detailed mechanisms for cardiac kinase regulation are established, far less is known …

Connexin 43 (Cx43) is most widely distributed in mammals, especially in the cardiovascular
and nervous systems. Its phosphorylation state has been found to be regulated by the action …

Selenium, a dietary trace mineral, essential for humans and animals, exerts its effects mainly
through its incorporation into selenoproteins. Adequate selenium intake is needed to …

Aim Cardiac hypertrophy and myocardial fibrosis significantly contribute to the pathogenesis
of diabetic cardiomyopathy (DCM). Altered expression of several genes and their regulation …