Epigenetic mechanisms—including DNA methylation, histone post-translational
modifications and changes in nucleosome positioning—regulate gene expression, cellular …

As the organ with the highest demand for oxygen, the brain has a poor tolerance to ischemia
and hypoxia. Despite severe ischemia/hypoxia induces the occurrence and development of …

Ischemic stroke (IS) is a detrimental neurological disease with limited treatments options. It
has been challenging to define the roles of brain cell subsets in IS onset and progression …

α2δ-1 (encoded by the Cacna2d1 gene) is a newly discovered NMDA receptor-interacting
protein and is the therapeutic target of gabapentinoids (eg, gabapentin and pregabalin) …

Epigenetic regulation of neuronal signalling through histone acetylation dictates
transcription programs that govern neuronal memory, plasticity and learning paradigms …

Background: The inhibition of histone deacetylase 9 (HDAC9) represents a promising
druggable target for stroke intervention. Indeed, HDAC9 is overexpressed in neurons after …

It has been documented that reactive oxygen species (ROS) contribute to oxidative stress,
leading to diseases such as ischemic heart disease. Recently, increasing evidence has …

Ischemic stroke is a detrimental neurological disease characterized by an irreversible infarct
core surrounded by an ischemic penumbra, a salvageable region of brain tissue. Unique …

High-throughput single-cell epigenomic assays can resolve cell type heterogeneity in
complex tissues, however, spatial orientation is lost. Here, we present single-cell …

Narrow therapeutic window limits treatments with thrombolysis and neuroprotection for most
stroke patients. Widening therapeutic window remains a critical challenge. Understanding …