Excessive sugar consumption is increasingly considered as a contributor to the emerging
epidemics of obesity and the associated cardiometabolic disease. Sugar is added to the diet …

A single entity, the AMP‐activated protein kinase (AMPK), phosphorylates and regulates in
vivo hydroxymethylglutraryl‐CoA reductase and acetyl‐CoA carboxylase (key regulatory …

Mammalian AMP-activated protein kinase and yeast SNF1 protein kinase are the central
components of kinase cascades that are highly conserved between animals, fungi, and …

The NH2-terminal domain of sterol-regulatory element binding protein-1a (SREBP-1a)
activates transcription of genes encoding enzymes of cholesterol and fatty acid biosynthesis …

Animals, including humans, express two isoforms of acetyl-CoA carboxylase (EC 6.4. 1.2),
ACC1 (M r= 265 kDa) and ACC2 (M r= 280 kDa). The predicted amino acid sequence of …

Fru-2, 6-P2 (fructose 2, 6-bisphosphate) is a signal molecule that controls glycolysis. Since
its discovery more than 20 years ago, inroads have been made towards the understanding …

▪ Abstract Long-chain fatty acids are involved in all aspects of cellular structure and function.
For controlling amounts of fatty acids, cells are endowed with two acetyl-coenzyme A …

Acetyl-CoA carboxylase (ACC) is rapidly regulated by reversible phosphorylation;
phosphorylation inactivates ACC, whereas dephosphorylation activates the enzyme. Among …

The product of the SNF1 gene is a protein kinase whose activity is essential for
transcriptional activation of glucose repressed genes in Saccharomyces cerevisiae. We …

In addition to acetyl-CoA carboxylase and HMG-CoA reductase, the AMP-activated protein
kinase phosphorylates glycogen synthase, phosphorylase kinase, hormone-sensitive lipase …