The genus Enterococcus includes some of the most important nosocomial multidrug-
resistant organisms, and these pathogens usually affect patients who are debilitated by …

The ribosome is one of the main antibiotic targets in the bacterial cell. Crystal structures of
naturally produced antibiotics and their semi-synthetic derivatives bound to ribosomal …

Drugs, their targets and the nature and number of drug targets | Nature Reviews Drug Discovery
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The discovery and implementation of antibiotics in the early twentieth century transformed
human health and wellbeing. Chemical synthesis enabled the development of the first …

The introduction of antibiotics into clinical practice revolutionized the treatment and
management of infectious diseases. Before the introduction of antibiotics, these diseases …

ABSTRACT A novel multidrug resistance phenotype mediated by the Cfr rRNA
methyltransferase is observed in Staphylococcus aureus and Escherichia coli. The cfr gene …

Approximately 40% of treatments of chronic and recurrent osteomyelitis fail in part due to
bacterial persistence. Staphylococcus aureus, the predominant pathogen in human …

Many clinically useful antibiotics exert their antimicrobial effects by blocking protein
synthesis on the bacterial ribosome. The structure of the ribosome has recently been …

Practical Handbook of Microbiology, 4th edition provides basic, clear and concise
knowledge and practical information about working with microorganisms. Useful to anyone …

Translation of mitochondrial messenger RNA (mt-mRNA) is performed by distinct
mitoribosomes comprising at least 36 mitochondria-specific proteins. How these …