Dopamine in Parkinson's disease

S Latif, M Jahangeer, DM Razia, M Ashiq, A Ghaffar… - Clinica chimica acta, 2021 - Elsevier
Parkinson's disease is a neurodegenerative disease caused by the death of neurons, ie,
cells critical to the production of dopamine, an important neurotransmitter in the brain. Here …

New modalities for challenging targets in drug discovery

E Valeur, SM Guéret, H Adihou… - Angewandte Chemie …, 2017 - Wiley Online Library
Our ever‐increasing understanding of biological systems is providing a range of exciting
novel biological targets, whose modulation may enable novel therapeutic options for many …

The 3D OrbiSIMS—label-free metabolic imaging with subcellular lateral resolution and high mass-resolving power

MK Passarelli, A Pirkl, R Moellers, D Grinfeld… - Nature …, 2017 - nature.com
We report the development of a 3D OrbiSIMS instrument for label-free biomedical imaging. It
combines the high spatial resolution of secondary ion mass spectrometry (SIMS; under 200 …

Advances in MALDI mass spectrometry imaging single cell and tissues

X Zhu, T Xu, C Peng, S Wu - Frontiers in Chemistry, 2022 - frontiersin.org
Compared with conventional optical microscopy techniques, mass spectrometry imaging
(MSI) or imaging mass spectrometry (IMS) is a powerful, label-free analytical technique …

Nanoantibiotics: Functions and properties at the nanoscale to combat antibiotic resistance

MM Mamun, AJ Sorinolu, M Munir… - Frontiers in …, 2021 - frontiersin.org
One primary mechanism for bacteria develo** resistance is frequent exposure to
antibiotics. Nanoantibiotics (nAbts) is one of the strategies being explored to counteract the …

Single‐cell mass spectrometry approaches to explore cellular heterogeneity

L Zhang, A Vertes - Angewandte Chemie International Edition, 2018 - Wiley Online Library
Compositional diversity is a fundamental property in cell populations. Single‐cell analysis
promises new insight into this cellular heterogeneity on the genomic, transcriptomic …

Image-guided MALDI mass spectrometry for high-throughput single-organelle characterization

DC Castro, YR **e, SS Rubakhin, EV Romanova… - Nature …, 2021 - nature.com
Peptidergic dense-core vesicles are involved in packaging and releasing neuropeptides
and peptide hormones—critical processes underlying brain, endocrine and exocrine …

Single Cell mass spectrometry: Towards quantification of small molecules in individual cells

Y Lan, Z Zou, Z Yang - TrAC Trends in Analytical Chemistry, 2024 - Elsevier
Studying cell heterogeneity can provide a deeper understanding of biological activities, but
appropriate studies cannot be performed using traditional bulk analysis methods. The …

Mass spectrometry imaging and integration with other imaging modalities for greater molecular understanding of biological tissues

T Porta Siegel, G Hamm, J Bunch, J Cappell… - Molecular imaging and …, 2018 - Springer
Over the last two decades, mass spectrometry imaging (MSI) has been increasingly
employed to investigate the spatial distribution of a wide variety of molecules in complex …

Plasmonic Coupling on an Optical Microfiber Surface: Enabling Single‐Molecule and Noninvasive Dopamine Detection

Y Huang, P Chen, L Zhou, J Zheng, H Wu… - Advanced …, 2023 - Wiley Online Library
Optical fibers can be effective biosensors when employed in early‐stage diagnostic point‐of‐
care devices as they can avoid interference from molecules with similar redox potentials …