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Dopamine in Parkinson's disease
Parkinson's disease is a neurodegenerative disease caused by the death of neurons, ie,
cells critical to the production of dopamine, an important neurotransmitter in the brain. Here …
cells critical to the production of dopamine, an important neurotransmitter in the brain. Here …
New modalities for challenging targets in drug discovery
E Valeur, SM Guéret, H Adihou… - Angewandte Chemie …, 2017 - Wiley Online Library
Our ever‐increasing understanding of biological systems is providing a range of exciting
novel biological targets, whose modulation may enable novel therapeutic options for many …
novel biological targets, whose modulation may enable novel therapeutic options for many …
The 3D OrbiSIMS—label-free metabolic imaging with subcellular lateral resolution and high mass-resolving power
MK Passarelli, A Pirkl, R Moellers, D Grinfeld… - Nature …, 2017 - nature.com
We report the development of a 3D OrbiSIMS instrument for label-free biomedical imaging. It
combines the high spatial resolution of secondary ion mass spectrometry (SIMS; under 200 …
combines the high spatial resolution of secondary ion mass spectrometry (SIMS; under 200 …
Advances in MALDI mass spectrometry imaging single cell and tissues
X Zhu, T Xu, C Peng, S Wu - Frontiers in Chemistry, 2022 - frontiersin.org
Compared with conventional optical microscopy techniques, mass spectrometry imaging
(MSI) or imaging mass spectrometry (IMS) is a powerful, label-free analytical technique …
(MSI) or imaging mass spectrometry (IMS) is a powerful, label-free analytical technique …
Nanoantibiotics: Functions and properties at the nanoscale to combat antibiotic resistance
One primary mechanism for bacteria develo** resistance is frequent exposure to
antibiotics. Nanoantibiotics (nAbts) is one of the strategies being explored to counteract the …
antibiotics. Nanoantibiotics (nAbts) is one of the strategies being explored to counteract the …
Single‐cell mass spectrometry approaches to explore cellular heterogeneity
L Zhang, A Vertes - Angewandte Chemie International Edition, 2018 - Wiley Online Library
Compositional diversity is a fundamental property in cell populations. Single‐cell analysis
promises new insight into this cellular heterogeneity on the genomic, transcriptomic …
promises new insight into this cellular heterogeneity on the genomic, transcriptomic …
Image-guided MALDI mass spectrometry for high-throughput single-organelle characterization
Peptidergic dense-core vesicles are involved in packaging and releasing neuropeptides
and peptide hormones—critical processes underlying brain, endocrine and exocrine …
and peptide hormones—critical processes underlying brain, endocrine and exocrine …
Single Cell mass spectrometry: Towards quantification of small molecules in individual cells
Studying cell heterogeneity can provide a deeper understanding of biological activities, but
appropriate studies cannot be performed using traditional bulk analysis methods. The …
appropriate studies cannot be performed using traditional bulk analysis methods. The …
Mass spectrometry imaging and integration with other imaging modalities for greater molecular understanding of biological tissues
T Porta Siegel, G Hamm, J Bunch, J Cappell… - Molecular imaging and …, 2018 - Springer
Over the last two decades, mass spectrometry imaging (MSI) has been increasingly
employed to investigate the spatial distribution of a wide variety of molecules in complex …
employed to investigate the spatial distribution of a wide variety of molecules in complex …
Plasmonic Coupling on an Optical Microfiber Surface: Enabling Single‐Molecule and Noninvasive Dopamine Detection
Optical fibers can be effective biosensors when employed in early‐stage diagnostic point‐of‐
care devices as they can avoid interference from molecules with similar redox potentials …
care devices as they can avoid interference from molecules with similar redox potentials …