Angiogenesis is a normal biological process wherein new blood vessels form from the
growth of pre-existing blood vessels. Preventing angiogenesis in solid tumours by targeting …

Rapidly renewing tissues such as the intestinal epithelium critically depend on the activity of
small-sized stem cell populations that continuously generate new progeny to replace lost …

Luteinizing hormone and chorionic gonadotropin are glycoprotein hormones that are related
to follicle-stimulating hormone and thyroid-stimulating hormone,. Luteinizing hormone and …

The four R-spondins (RSPO1–4) strongly potentiate Wnt signaling and play critical roles in
normal development, adult stem cell survival, and cancer development and aggressiveness …

The tumour suppressors RNF43 and ZNRF3 play a central role in development and tissue
homeostasis by promoting the turnover of the Wnt receptors LRP6 and Frizzled (FZD). The …

Leucine-rich repeat-containing G protein–coupled receptor 5 (LGR5) is a bona fide marker
of adult stem cells in several epithelial tissues, most notably in the intestinal crypts, and is …

Axon guidance relies on a combinatorial code of receptor and ligand interactions that direct
adhesive/attractive and repulsive cellular responses. Recent structural data have revealed …

R-spondins (RSPOs) amplify WNT signaling during development and regenerative
responses. We previously demonstrated that RSPOs 2 and 3 potentiate WNT/β-catenin …

WNT/β-catenin signaling plays key roles in development and cancer,. ZNRF3/RNF43
modulates Frizzleds through ubiquitination, dampening WNT/β-catenin signaling …

LGR4 and LGR5 are two homologous receptors that potentiate Wnt/β-catenin signaling in
response to R-spondin (RSPO) ligands. The RSPO and LGR4 complex binds to and inhibits …