Tumorigenesis begins long before the growth of a clinically detectable lesion and, indeed,
even before any of the usual morphological correlates of pre-malignancy are recognizable …

BACKGROUND & AIMS: Heritable factors contribute to the development of colorectal
cancer. Identifying the genetic loci associated with colorectal tumor formation could …

To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-
genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence …

Background & Aims Guidelines for initiating colorectal cancer (CRC) screening are based
on family history but do not consider lifestyle, environmental, or genetic risk factors. We …

Multiple regulatory elements distant from their targets on the linear genome can influence
the expression of a single gene through chromatin loo**. Chromosome conformation …

Hereditary mixed polyposis syndrome (HMPS) is characterized by apparent autosomal
dominant inheritance of multiple types of colorectal polyp, with colorectal carcinoma …

Known genetic loci explain only a small proportion of the familial relative risk of colorectal
cancer (CRC). We conducted a genome-wide association study of CRC in East Asians with …

Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a
strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases …

Background & Aims Estimates of absolute risk of colorectal cancer (CRC) are needed to
facilitate communication and better inform the public about the potentials and limits of cancer …

Colorectal cancer (CRC) is a complex disease that develops as a consequence of both
genetic and environmental risk factors. A small proportion (3–5%) of cases arise from …