Dissecting metastasis using preclinical models and methods
Metastasis has long been understood to lead to the overwhelming majority of cancer-related
deaths. However, our understanding of the metastatic process, and thus our ability to …
deaths. However, our understanding of the metastatic process, and thus our ability to …
Check your cultures! A list of cross‐contaminated or misidentified cell lines
A Capes‐Davis, G Theodosopoulos… - … journal of cancer, 2010 - Wiley Online Library
Continuous cell lines consist of cultured cells derived from a specific donor and tissue of
origin that have acquired the ability to proliferate indefinitely. These cell lines are well …
origin that have acquired the ability to proliferate indefinitely. These cell lines are well …
Epigenetic and genetic features of 24 colon cancer cell lines
D Ahmed, PW Eide, IA Eilertsen, SA Danielsen… - Oncogenesis, 2013 - nature.com
Cell lines are invaluable biomedical research tools, and recent literature has emphasized
the importance of genotype authentication and characterization. In the present study, 24 out …
the importance of genotype authentication and characterization. In the present study, 24 out …
Organoid cultures for the analysis of cancer phenotypes
Preclinical models of cancer are essential for a basic understanding of cancer biology and
its translation into efficient treatment options for affected patients. Cancer cell lines and …
its translation into efficient treatment options for affected patients. Cancer cell lines and …
Choosing the right cell line for renal cell cancer research
Cell lines are still a tool of choice for many fields of biomedical research, including oncology.
Although cancer is a very complex disease, many discoveries have been made using …
Although cancer is a very complex disease, many discoveries have been made using …
Modeling pancreatic cancer with organoids
Pancreatic ductal adenocarcinoma (PDA) is a highly lethal malignancy for which new
treatment and diagnostic approaches are urgently needed. For such breakthroughs to be …
treatment and diagnostic approaches are urgently needed. For such breakthroughs to be …
CD133 as a biomarker for putative cancer stem cells in solid tumours: limitations, problems and challenges
P Grosse‐Gehling, CA Fargeas, C Dittfeld… - The Journal of …, 2013 - Wiley Online Library
The cancer stem cell (CSC) hypothesis, despite the limitations of the currently available
models and assays, has ushered in a new era of excitement in cancer research. The …
models and assays, has ushered in a new era of excitement in cancer research. The …
[HTML][HTML] Global computational alignment of tumor and cell line transcriptional profiles
A Warren, Y Chen, A Jones, T Shibue, WC Hahn… - Nature …, 2021 - nature.com
Cell lines are key tools for preclinical cancer research, but it remains unclear how well they
represent patient tumor samples. Direct comparisons of tumor and cell line transcriptional …
represent patient tumor samples. Direct comparisons of tumor and cell line transcriptional …
Ex Vivo Tumor Culture Systems for Functional Drug Testing and Therapy Response Prediction
TG Meijer, KAT Naipal, A Jager, DC van Gent - Future science OA, 2017 - Taylor & Francis
Optimal patient stratification is of utmost importance in the era of personalized medicine.
Prediction of individual treatment responses by functional ex vivo assays requires model …
Prediction of individual treatment responses by functional ex vivo assays requires model …
Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments
X Zhang, M Fryknäs, E Hernlund, W Fayad… - Nature …, 2014 - nature.com
Abnormal vascularization of solid tumours results in the development of microenvironments
deprived of oxygen and nutrients that harbour slowly growing and metabolically stressed …
deprived of oxygen and nutrients that harbour slowly growing and metabolically stressed …