The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …

Antitumor therapeutic strategies that fundamentally rely on the induction of DNA damage to
eradicate and inhibit the growth of cancer cells are integral approaches to cancer therapy …

The tumor protein TP53 gene, encoding the cellular tumor antigen p53, is the single most
frequently mutated gene in human cancers. p53 plays a central role in responding to DNA …

Elevated concentration of homocysteine (Hcy) in the blood plasma, hyperhomocysteinemia
(HHcy), has been implicated in various disorders, including cardiovascular and …

Programmed cell death (PCD) pathways, including apoptosis and regulated necrosis, are
required for normal cell turnover and tissue homeostasis. Mis-regulation of PCD is …

MicroRNAs (miRNAs) are endogenous 22 nt non-coding RNAs that target mRNAs for
cleavage or translational repression. Numerous miRNAs regulate programmed cell death …

Abstract Interleukin (IL)‐22 is known to play a key role in promoting antimicrobial immunity,
inflammation, and tissue repair at barrier surfaces by binding to the receptors, IL‐10R2 and …

Liver injury is a common pathological process, which can result in fatty liver, cirrhosis,
fibrosis and even cancer. Polysaccharides isolated from plants have been regarded as an …

Senescence of alveolar type 2 (ATII) cells, progenitors of the alveolar epithelium, is
implicated in the pathogeneses of idiopathic pulmonary fibrosis (IPF), an aging‐related …

Recent research has demonstrated that microRNAs (miRNAs) are key regulators of many
cell processes often deregulated in cancer, including apoptosis. Indeed, it is becoming clear …