Nano-formulations for pulmonary delivery: Past, present, and future perspectives

S Peng, W Wang, R Zhang, C Wu, X Pan, Z Huang - Pharmaceutics, 2024 - mdpi.com
With the development of nanotechnology and confronting the problems of traditional
pharmaceutical formulations in treating lung diseases, inhalable nano-formulations have …

Aerosol delivery devices for obstructive lung diseases

RA Pleasants, DR Hess - Respiratory Care, 2018 - liebertpub.com
Drug delivery by inhalation is the principal strategy to treat obstructive lung diseases, which
affect about 15% of the population in the United States. Aerosol delivery devices have …

Optimization of formulation and atomization of lipid nanoparticles for the inhalation of mRNA

H Miao, K Huang, Y Li, R Li, X Zhou, J Shi… - International Journal of …, 2023 - Elsevier
Lipid nanoparticles (LNPs) have demonstrated efficacy and safety for mRNA vaccine
administration by intramuscular injection; however, the pulmonary delivery of mRNA …

The function and performance of aqueous aerosol devices for inhalation therapy

TC Carvalho, JT McConville - Journal of Pharmacy and …, 2016 - academic.oup.com
Objectives In this review paper, we explore the interaction between the functioning
mechanism of different nebulizers and the physicochemical properties of the formulations for …

Protein stability in pulmonary drug delivery via nebulization

SP Hertel, G Winter, W Friess - Advanced drug delivery reviews, 2015 - Elsevier
Protein inhalation is a delivery route which offers high potential for direct local lung
application of proteins. Liquid formulations are usually available in early stages of …

Inhaled colistin monotherapy for respiratory tract infections in adults without cystic fibrosis: a systematic review and meta-analysis

KZ Vardakas, GL Voulgaris, G Samonis… - International journal of …, 2018 - Elsevier
Background Inhaled colistin is becoming increasingly popular against respiratory tract
infections caused by multidrug resistant (MDR) Gram-negative bacteria because it may …

Inhalation therapy in patients receiving mechanical ventilation: an update

A Ari, JB Fink, R Dhand - … of aerosol medicine and pulmonary drug …, 2012 - liebertpub.com
Incremental gains in understanding the influence of various factors on aerosol delivery in
concert with technological advancements over the past 2 decades have fueled an ever …

[HTML][HTML] How should aerosols be delivered during invasive mechanical ventilation?

R Dhand - Respiratory care, 2017 - liebertpub.com
The delivery of aerosols to mechanically ventilated patients presents unique challenges and
differs from inhaled drug delivery in spontaneously breathing patients in several respects …

Devices for improved delivery of nebulized pharmaceutical aerosols to the lungs

W Longest, B Spence, M Hindle - Journal of aerosol medicine and …, 2019 - liebertpub.com
Nebulizers have a number of advantages for the delivery of inhaled pharmaceutical
aerosols, including the use of aqueous formulations and the ability to deliver process …

Development and characterization of inhaled nintedanib-loaded PLGA nanoparticles using scalable high-pressure homogenization technique

X Wang, D Gadhave, G Chauhan, V Gupta - Journal of Drug Delivery …, 2024 - Elsevier
Presently, non-invasive targeted drug delivery to the lungs represents a routinely
investigated approach to treat challenging disorders such as pulmonary fibrosis. Nintedanib …