Mechanisms of botulinum toxin type A action on pain
Already a well-established treatment for different autonomic and movement disorders, the
use of botulinum toxin type A (BoNT/A) in pain conditions is now continuously expanding …
use of botulinum toxin type A (BoNT/A) in pain conditions is now continuously expanding …
Botulinum toxin for neuropathic pain: a review of the literature
HM Oh, ME Chung - Toxins, 2015 - mdpi.com
Botulinum neurotoxin (BoNT), derived from Clostridium botulinum, has been used
therapeutically for focal dystonia, spasticity, and chronic migraine. Its spectrum as a potential …
therapeutically for focal dystonia, spasticity, and chronic migraine. Its spectrum as a potential …
Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons
Botulinum neurotoxin E (BoNT/E) can cause paralysis in humans and animals by blocking
neurotransmitter release from presynaptic nerve terminals. How this toxin targets and enters …
neurotransmitter release from presynaptic nerve terminals. How this toxin targets and enters …
Botulinum toxin A, brain and pain
Botulinum neurotoxin type A (BoNT/A) is one of the most potent toxins known and a potential
biological threat. At the same time, it is among the most widely used therapeutic proteins …
biological threat. At the same time, it is among the most widely used therapeutic proteins …
[HTML][HTML] Current prophylactic medications for migraine and their potential mechanisms of action
A relatively high number of different medications is currently used for migraine prevention in
clinical practice. Although these compounds were initially developed for other indications …
clinical practice. Although these compounds were initially developed for other indications …
Control of autophagosome axonal retrograde flux by presynaptic activity unveiled using botulinum neurotoxin type a
Botulinum neurotoxin type A (BoNT/A) is a highly potent neurotoxin that elicits flaccid
paralysis by enzymatic cleavage of the exocytic machinery component SNAP25 in motor …
paralysis by enzymatic cleavage of the exocytic machinery component SNAP25 in motor …
Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+
Neuronal communication is mediated by Ca2+-triggered fusion of transmitter-filled synaptic
vesicles with the presynaptic plasma membrane. Synaptotagmin I functions as a Ca2+ …
vesicles with the presynaptic plasma membrane. Synaptotagmin I functions as a Ca2+ …
More than at the neuromuscular synapse: actions of botulinum neurotoxin A in the central nervous system
R Mazzocchio, M Caleo - The Neuroscientist, 2015 - journals.sagepub.com
Botulinum neurotoxin type A (BoNT/A) is a metalloprotease that produces a sustained yet
transitory blockade of transmitter release from peripheral nerve terminals. Local delivery of …
transitory blockade of transmitter release from peripheral nerve terminals. Local delivery of …
The botulinum toxin as a therapeutic agent: molecular structure and mechanism of action in motor and sensory systems
R Kumar, HP Dhaliwal, RV Kukreja… - Seminars in …, 2016 - thieme-connect.com
Botulinum neurotoxin (BoNT) produced by Clostridium botulinum is the most potent
molecule known to mankind. Higher potency of BoNT is attributed to several factors …
molecule known to mankind. Higher potency of BoNT is attributed to several factors …
Botulinum neurotoxin serotype A specific cell-based potency assay to replace the mouse bioassay
E Fernandez-Salas, J Wang, Y Molina, JB Nelson… - PLoS …, 2012 - journals.plos.org
Botulinum neurotoxin serotype A (BoNT/A), a potent therapeutic used to treat various
disorders, inhibits vesicular neurotransmitter exocytosis by cleaving SNAP25. Development …
disorders, inhibits vesicular neurotransmitter exocytosis by cleaving SNAP25. Development …