Noncoding RNA therapeutics—challenges and potential solutions

M Winkle, SM El-Daly, M Fabbri, GA Calin - Nature reviews Drug …, 2021 - nature.com
Therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …

Current challenges and future opportunities of phage therapy

DP Pires, AR Costa, G Pinto, L Meneses… - FEMS microbiology …, 2020 - academic.oup.com
Antibiotic resistance is a major public health challenge worldwide, whose implications for
global health might be devastating if novel antibacterial strategies are not quickly …

Drug delivery strategies for antibiofilm therapy

V Choi, JL Rohn, P Stoodley, D Carugo… - Nature Reviews …, 2023 - nature.com
Although new antibiofilm agents have been developed to prevent and eliminate pathogenic
biofilms, their widespread clinical use is hindered by poor biocompatibility and …

[HTML][HTML] Recent advances in bacteriophage-based therapeutics: Insight into the post-antibiotic era

H Ling, X Lou, Q Luo, Z He, M Sun, J Sun - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Antibiotic resistance is one of the biggest threats to global health, as it can make the
treatment of bacterial infections in humans difficult owing to their high incidence rate …

Phage therapy—challenges, opportunities and future prospects

B Zalewska-Piątek - Pharmaceuticals, 2023 - mdpi.com
The increasing drug resistance of bacteria to commonly used antibiotics creates the need to
search for and develop alternative forms of treatment. Phage therapy fits this trend perfectly …

Encapsulation and delivery of phage as a novel method for gut flora manipulation in situ: A review

Y Yang, H Du, G Zou, Z Song, Y Zhou, H Li… - Journal of Controlled …, 2023 - Elsevier
Intestinal flora regulation is an effective method to intervene and treat diseases associated
with microbiome imbalance. In addition to conventional probiotic supplement, phage …

Factors determining phage stability/activity: challenges in practical phage application

E Jończyk-Matysiak, N Łodej, D Kula… - Expert review of anti …, 2019 - Taylor & Francis
Introduction: Phages consist of nucleic acids and proteins that may lose their activity under
different physico-chemical conditions. The production process of phage formulations may …

Interactions of bacteriophages with animal and human organisms—safety issues in the light of phage therapy

M Podlacha, Ł Grabowski… - International journal of …, 2021 - mdpi.com
Bacteriophages are viruses infecting bacterial cells. Since there is a lack of specific
receptors for bacteriophages on eukaryotic cells, these viruses were for a long time …

Combination of bacteriophages and vancomycin in a co-delivery hydrogel for localized treatment of fracture-related infections

B Chen, L Ponce Benavente, M Chittò, V Post… - npj Biofilms and …, 2024 - nature.com
Abstract Fracture-related infections (FRIs), particularly those caused by methicillin-resistant
Staphylococcus aureus (MRSA), are challenging to treat. This study designed and evaluated …

Nanocap**-enabled charge reversal generates cell-enterable endosomal-escapable bacteriophages for intracellular pathogen inhibition

L Meng, F Yang, Y Pang, Z Cao, F Wu, D Yan… - Science Advances, 2022 - science.org
Bacteriophages (phages) are widely explored as antimicrobials for treating infectious
diseases due to their specificity and potency to infect and inhibit host bacteria. However, the …