Noncoding RNA therapeutics—challenges and potential solutions
Therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …
Current challenges and future opportunities of phage therapy
Antibiotic resistance is a major public health challenge worldwide, whose implications for
global health might be devastating if novel antibacterial strategies are not quickly …
global health might be devastating if novel antibacterial strategies are not quickly …
Drug delivery strategies for antibiofilm therapy
Although new antibiofilm agents have been developed to prevent and eliminate pathogenic
biofilms, their widespread clinical use is hindered by poor biocompatibility and …
biofilms, their widespread clinical use is hindered by poor biocompatibility and …
[HTML][HTML] Recent advances in bacteriophage-based therapeutics: Insight into the post-antibiotic era
H Ling, X Lou, Q Luo, Z He, M Sun, J Sun - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Antibiotic resistance is one of the biggest threats to global health, as it can make the
treatment of bacterial infections in humans difficult owing to their high incidence rate …
treatment of bacterial infections in humans difficult owing to their high incidence rate …
Phage therapy—challenges, opportunities and future prospects
B Zalewska-Piątek - Pharmaceuticals, 2023 - mdpi.com
The increasing drug resistance of bacteria to commonly used antibiotics creates the need to
search for and develop alternative forms of treatment. Phage therapy fits this trend perfectly …
search for and develop alternative forms of treatment. Phage therapy fits this trend perfectly …
Encapsulation and delivery of phage as a novel method for gut flora manipulation in situ: A review
Intestinal flora regulation is an effective method to intervene and treat diseases associated
with microbiome imbalance. In addition to conventional probiotic supplement, phage …
with microbiome imbalance. In addition to conventional probiotic supplement, phage …
Factors determining phage stability/activity: challenges in practical phage application
E Jończyk-Matysiak, N Łodej, D Kula… - Expert review of anti …, 2019 - Taylor & Francis
Introduction: Phages consist of nucleic acids and proteins that may lose their activity under
different physico-chemical conditions. The production process of phage formulations may …
different physico-chemical conditions. The production process of phage formulations may …
Interactions of bacteriophages with animal and human organisms—safety issues in the light of phage therapy
Bacteriophages are viruses infecting bacterial cells. Since there is a lack of specific
receptors for bacteriophages on eukaryotic cells, these viruses were for a long time …
receptors for bacteriophages on eukaryotic cells, these viruses were for a long time …
Combination of bacteriophages and vancomycin in a co-delivery hydrogel for localized treatment of fracture-related infections
B Chen, L Ponce Benavente, M Chittò, V Post… - npj Biofilms and …, 2024 - nature.com
Abstract Fracture-related infections (FRIs), particularly those caused by methicillin-resistant
Staphylococcus aureus (MRSA), are challenging to treat. This study designed and evaluated …
Staphylococcus aureus (MRSA), are challenging to treat. This study designed and evaluated …
Nanocap**-enabled charge reversal generates cell-enterable endosomal-escapable bacteriophages for intracellular pathogen inhibition
Bacteriophages (phages) are widely explored as antimicrobials for treating infectious
diseases due to their specificity and potency to infect and inhibit host bacteria. However, the …
diseases due to their specificity and potency to infect and inhibit host bacteria. However, the …