Enhancer target prediction: state-of-the-art approaches and future prospects
Enhancers are genomic regions that regulate gene transcription and are located far away
from the transcription start sites of their target genes. Enhancers are highly enriched in …
from the transcription start sites of their target genes. Enhancers are highly enriched in …
Leveraging Tissue-Specific Enhancer–Target Gene Regulatory Networks Identifies Enhancer Somatic Mutations That Functionally Impact Lung Cancer
Enhancers are noncoding regulatory DNA regions that modulate the transcription of target
genes, often over large distances along with the genomic sequence. Enhancer alterations …
genes, often over large distances along with the genomic sequence. Enhancer alterations …
Integrating long-range regulatory interactions to predict gene expression using graph convolutional networks
Long-range regulatory interactions among genomic regions are critical for controlling gene
expression, and their disruption has been associated with a host of diseases. However …
expression, and their disruption has been associated with a host of diseases. However …
[HTML][HTML] Harnessing PROTAC technology to combat stress hormone receptor activation
M Gazorpak, KM Hugentobler, D Paul… - Nature …, 2023 - nature.com
Counteracting the overactivation of glucocorticoid receptors (GR) is an important therapeutic
goal in stress-related psychiatry and beyond. The only clinically approved GR antagonist …
goal in stress-related psychiatry and beyond. The only clinically approved GR antagonist …
An upstream enhancer and MEF2 transcription factors fine-tune the regulation of the Bdnf gene in cortical and hippocampal neurons
A Avarlaid, K Falkenberg, K Lehe, G Mudò… - Journal of Biological …, 2024 - ASBMB
The myocyte enhancer factor (MEF2) family of transcription factors, originally discovered for
its pivotal role in muscle development and function, has emerged as an essential regulator …
its pivotal role in muscle development and function, has emerged as an essential regulator …
Landscape and perturbation of enhancer-driven core transcription regulatory circuits in cancer
J Xu, T Jiang, J Guo, T Pan, Y Li - Molecular Therapy-Nucleic Acids, 2023 - cell.com
Enhancers are emerging as critical regulatory regions in regulating gene expression across
diverse tissues and cell types. Perturbation of enhancer-driven transcriptional regulatory …
diverse tissues and cell types. Perturbation of enhancer-driven transcriptional regulatory …
IVEA: an integrative variational Bayesian inference method for predicting enhancer–gene regulatory interactions
Y Kimura, Y Ono, K Katayama… - Bioinformatics Advances, 2024 - academic.oup.com
Motivation Enhancers play critical roles in cell-type-specific transcriptional control. Despite
the identification of thousands of candidate enhancers, unravelling their regulatory …
the identification of thousands of candidate enhancers, unravelling their regulatory …
[BOOK][B] Computational Reconstruction of Enhancer-Gene Regulatory Networks Altered in Cancer
JM Hariprakash - 2022 - search.proquest.com
Enhancers are cis-acting non-coding regulatory elements that regulate the transcriptional
output of target genes. Their dysregulation has been associated with various diseases …
output of target genes. Their dysregulation has been associated with various diseases …
Ienhancer-Flow: Integrating Transformer-Based Sequence Learning with DNA Shape Insights for Robust Enhancer Prediction
H Liu, H Luo, L Luo - Available at SSRN 5074657 - papers.ssrn.com
AbstractObjective: Enhancers are critical non-coding regulatory elements, but their
prediction remains challenging due to their variability and the absence of clear sequence …
prediction remains challenging due to their variability and the absence of clear sequence …