Excitotoxicity contributes to neuronal degeneration in many acute CNS diseases, including
ischemia, trauma, and epilepsy, and may also play a role in chronic diseases, such as …

Neuroprotection for ischemic stroke refers to strategies, applied singly or in combination, that
antagonize the injurious biochemical and molecular events that eventuate in irreversible …

Background—This review article deals with the role of calcium in ischemic cell death. A
calcium-related mechanism was proposed more than two decades ago to explain cell …

Stroke and neurotrauma mediate neuronal death through a series of events that involve
multiple interdependent molecular pathways. It has been suggested that these pathways are …

Excitotoxicity is one of the most extensively studied processes of neuronal cell death, and
plays an important role in many central nervous system (CNS) diseases, including CNS …

OBJECTIVE: Experimental models and clinical observations of acute spinal cord injury (SCI)
support the concepts of primary and secondary injury, in which the initial mechanical insult is …

The N‐methyl‐D‐aspartate receptors (NMDARs) are ionotropic glutamate receptors that
mediate the flux of calcium (Ca2+) into the post‐synaptic compartment. Ca2+ influx …

Cerebral concussion is both the most common and most puzzling type of traumatic brain
injury (TBI). It is normally produced by acceleration (or deceleration) of the head and is …

Background and Objective: Stroke is a leading cause of morbidity and mortality in both
developed and develo** countries all over the world. The only drug for ischemic stroke …

Evidence accumulated over more than two decades has implicated Ca2+ dysregulation in
brain aging and Alzheimer's disease (AD), giving rise to the Ca2+ hypothesis of brain aging …