The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …

Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor
aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and …

Improving the solubility and permeability of drugs via cocrystallization is an important theme
in crystal engineering with practical applications for the discovery and development of high …

Nanoparticles (NPs) are of the most interesting novel vehicles for effective drug delivery to
humans. Freeze drying is known as an engaging process to improve the long lasting stability …

Ternary co-crystal, as a novel co-crystal design strategy developed on the basis of binary co-
crystal, could be used to improve the physicochemical properties of active pharmaceutical …

The marketed formulation of pazopanib (PAZ) suffers from low and variable bioavailability
because of its poor dissolution rate and photostability issues. The drug falls under …

New crystalline forms of bumetanide, namely, four cocrystals, two salts, and one salt-
cocrystal were crystallized. Urea and lactams such as valerolactam, caprolactam, and N …

The synthesis of multicomponent cocrystals and salts (MCCS) is an active and contemporary
theme in the crystal engineering of pharmaceutical crystal forms. The self-assembly process …

Among the various strategies for increasing aqueous solubility of pharmaceutical
substances, cocrystals have been emerging as a promising alternative. The ferulic acid …

According to the BCS classification system, the differentiation of drugs is based on two
essential parameters of solubility and permeability, meaning the latter is as pivotal as the …